Results 221 to 230 of about 36,294 (262)

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Biological equivalence of additive manufacturing titanium vs conventional implants in peri-implantitis. [PDF]

Braz Dent J
Carvalho PHA, Bassi APF, Bizelli VF, Oliveira JF, Gabrielli MAC, Pereira-Filho VA.   +5 more
europepmc   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

CRP Deficiency Rescues Periodontitis-Induced Hippocampal Neurogenesis Impairment by Suppressing OPC-Derived BMP4 Signaling in Rats. [PDF]

Adv Sci (Weinh)
Li L, Deng P, Hou S, Xia X, Zhao W, Zhu X, Zhang Y, Wang C, Xu L, Song J.   +9 more
europepmc   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Perioperative outcomes of 65 dogs and 15 cats undergoing lung lobectomies with a hilar circumferential ligature. [PDF]

Vet Surg
Cronin AM, Bird F, Vlasin M, Miles JE, Kaczmarek J, Hall JL.   +5 more
europepmc   +1 more source

Mechanistic and Therapeutic Insights into Nrf2-Mediated Redox Regulation in Periodontitis. [PDF]

Antioxidants (Basel)
Wada S, Nakano H, Sawai Y, Yamauchi Y, Hasumoto M, Mitate E, Demura N.   +6 more
europepmc   +1 more source

Surgical field visualization and feasibility of accessory lung lobectomy using a pretied ligature loop via single incision thoracoscopy in canine cadavers. [PDF]

Front Vet Sci
Kim C, Lee S, Heo S.
europepmc   +1 more source

Evaluation of the rate of residual polystomatic sublingual acinar tissue without tunneling dorsal to the digastricus using a ventral or ventrolateral approach in cats. [PDF]

Vet Surg
Mullins RA, Marirrodriga Larrocha I, Ortega Jusdado C, Otero Balda I, Kelly PA.   +4 more
europepmc   +1 more source

Neck Findings in Hanging: A Cross-Sectional Comparative Study of Conventional Autopsy and Postmortem CT-Based Virtual Autopsy. [PDF]

Cureus
Slong D, Das P, S K, Naidu LRV, Mukherjee B, Lynser D, Ropmay AD, Patowary AJ.   +7 more
europepmc   +1 more source