Results 291 to 300 of about 80,787 (394)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Investigating the Effects of Heated Tobacco Products on Periodontal Healing: Insights From In Vivo and In Vitro Experiments. [PDF]

Cureus
Doya K, Imamura K, Mori S, Nakane-Koyachi S, Kokubu E, Ishihara K, Saito A.   +6 more
europepmc   +1 more source

Crystalline‐Amorphous Heterostructure: A Novel Configuration for Silver Nanoclusters

Advanced Science, EarlyView.
This study presents a spontaneously formed amorphous‐crystalline heterostructure composite composed of atomically precise carboranylthiolate‐protected silver NCs, demonstrating not only a unique co‐assembly of distinct metal NCs at the macroscopic level but also promising potential applications of metal cluster‐based materials.
Jia‐Hong Huang, Yao Cui, Peng Luo, Zhao‐Yang Wang, Shuang‐Quan Zang   +4 more
wiley   +1 more source

Right lower lobectomy and lymph node dissection for lung cancer with subcarinal bronchial diverticulum. [PDF]

J Surg Case Rep
Iga N, Hayama Y, Yamada E, Muro M.
europepmc   +1 more source

NDRG1‐Driven Lactate Accumulation Promotes Lung Adenocarcinoma Progression Through the Induction of an Immunosuppressive Microenvironment

Advanced Science, EarlyView.
NDRG1 drives lactate accumulation and histone lactylation in lung adenocarcinoma, promoting immunosuppression via M2 macrophage polarization and CD8⁺ T cell inhibition. High NDRG1 expression correlates with poor prognosis, an immunosuppressive microenvironment, and immunotherapy resistance.
Gujie Wu, Hongxia Cheng, Jiacheng Yin, Yuansheng Zheng, Haochun Shi, Binyang Pan, Ming Li, Mengnan Zhao, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Guoshu Bi, Weigang Guo, Lin Wang, Yiwei Huang   +14 more
wiley   +1 more source

Circadian disruption by simulated shift work aggravates periodontitis via orchestrating BMAL1 and GSDMD-mediated pyroptosis. [PDF]

Int J Oral Sci
Wang Y, Li R, Ye Q, Fei D, Zhang X, Huang J, Liu T, Wang J, Wang Q.   +8 more
europepmc   +1 more source

Decrease of Pericytes is Associated With Liver Disease Caused by Ligature‐Induced Periodontitis in Rats

The Journal of Periodontology, 2017
D. Vasconcelos, Felipe Rodolfo Pereira da Silva, M. Pinto, L. A. B. Santana, I. G. Souza, Luan Kelves Miranda de Souza, Natássia Cristina Martins Oliveira, C. Ventura, P. Novaes, A. Barbosa, J. Medeiros, I. Mikolasevic, A. Mani, J. Soares de Oliveira   +13 more
semanticscholar   +1 more source

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Concealed Homicide in a Sexually Abused Child. [PDF]

Acad Forensic Pathol
Patlakwe TM, Saniotis A, Mvula N.
europepmc   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
wiley   +1 more source