Results 101 to 110 of about 8,648,665 (313)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Tunable Color Emissions in a Single CdTe Nanowire Based on Complex Optical Transverse Nonlinear Effects

Photonics
Tunable color emissions, emerging from a single CdTe nanowire, are demonstrated experimentally based on optical transverse nonlinear effects. The pumping light at different wavelengths (e.g., 1064 nm and 980 nm) is coupled to a nanowire at both ends via ...
Lijun Guo, Lihao Xu, Changjiang Fan, Yunfei Zhang, Hao Yang, Mengwei Li, Chenguang Xin   +6 more
doaj   +1 more source

Process feasibility study in support of silicon material, task 1 [PDF]

Analyses of process system properties were continued for materials involved in the alternate processes under consideration for semiconductor silicon. Primary efforts centered on physical and thermodynamic property data for dichlorosilane.
Hansen, K. C., Li, K. Y., Yaws, C. L.
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Use of Fuel Gas as Stripping Medium in Atmospheric Distillation of Crude Oil L’utilisation de gaz combustible comme moyen d’extraction des fractions légères en distillation atmosphérique du pétrole brut

Oil & Gas Science and Technology, 2011
Stripping of petroleum fractions aims to remove the light ends that spoil some of their properties, such as the flash point. Stripping usually employs steam for that purpose.
Plellis-Tsaltakis C., Lygeros A.I.
doaj   +1 more source

Jet fuel property changes and their effect on producibility and cost in the U.S., Canada, and Europe [PDF]

The effects of changes in properties and blending stocks on the refinery output and cost of jet fuel in the U.S., Canada, and Europe were determined. Computerized refinery models that minimize production costs and incorporated a 1981 cost structure and ...
Avella, A. J., Jr., Cunningham, A. R., Featherston, C. D., Gorgol, J. F., Graf, A. J., Lieberman, M., Oliver, G. A., Varga, G. M., Jr.   +7 more
core   +1 more source

Flash Point and Chemical Composition of Aviation Kerosene (Jet A) [PDF]

, 2000
The relationship between chemical composition, flash point, and ignition energy was examined for eight samples of aviation kerosene (Jet A) with flash points between 29°C (84°F) and 74°C (165°F).
Lee, J. J., Nuyt, C. D., Shepherd, J. E., Woodrow, J. E.   +3 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

System for monitoring and controlling unit operations that include distillation [PDF]

, 2009
Fluid sensor methods and systems adapted for monitoring and/or controlling distillation operations in fluidic systems, such as bath distillation operations or continuous distillation operations, are disclosed.
Bennett, James, Carlson, Eric, Cypes, Stephen, Kolosov, Oleg, Matsiev, L, Padowitz, David, Uhrich, M   +6 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source