Results 111 to 120 of about 8,648,665 (313)
Identification of the main barriers to Ku accumulation in chromatin
Cell ReportsSummary: Repair of DNA double-strand breaks by the non-homologous end-joining pathway is initiated by the binding of Ku to DNA ends. Multiple Ku proteins load onto linear DNAs in vitro.
Madeleine Bossaert +8 more
doaj +1 more source
Jet A Explosion Experiments: Laboratory Testing [PDF]
, 1997 This report describes a series of experiments and analyses on the flammability of Jet A (aviation kerosene) in air. This is a progress report on ongoing work.
Krok, J. Christopher +2 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
The Restoration of Hope and Dignity in the Context of the Sexual Abuse Crisis in the Church
Communio ViatorumThis article looks at the sexual abuse crises that have hit churches around the world, especially the Roman Catholic Church, and asks if it is possible to talk of hope in such circumstances. It asks whether theology has a role to play or a responsibility
Peter De Mey
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Computer model for refinery operations with emphasis on jet fuel production. Volume 2: Data and technical bases [PDF]
The FORTRAN computing program predicts the flow streams and material, energy, and economic balances of a typical petroleum refinery, with particular emphasis on production of aviation turbine fuel of varying end point and hydrogen content specifications.
Dunbar, D. N., Tunnah, B. G.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Computer model for refinery operations with emphasis on jet fuel production. Volume 3: Detailed systems and programming documentation [PDF]
The FORTRAN computing program predicts flow streams and material, energy, and economic balances of a typical petroleum refinery, with particular emphasis on production of aviation turbine fuels of varying end point and hydrogen content specifications ...
Dunbar, D. N., Tunnah, B. G.
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source