Results 131 to 140 of about 8,648,665 (313)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Energy and precious fuels requirements of fuel alcohol production. Volume 4: Appendices G and H, methanol from coal [PDF]
Coal mine location, mining technology, energy consumption in mining, coal transport, and potential availability of coal are discussed.
Back, G., Reddy, T. S., Weinblatt, H.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Prediction of crude oil light end yields using neural network modeling
, 2000 The objective of the project is to explore the feasibility of using neural network modeling technique to predict the yields of light hydrocarbon (specifically propane and butane) in crude oil, using easily measurable crude oil properties, such as specific gravity (S.G.) and yields of the various crude oil fractions. Another objective of this project is
openaire +1 more source
Determination of thermodynamic properties of AeroZINE-50, phase 1 [PDF]
Literature survey of, and test procedure for determination of thermodynamic properties of AeroZINE ...
Copeland, J. P. +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Fuel quality-processing study. Volume 2: Literature survey [PDF]
The validity of initial assumptions about raw materials choices and relevant upgrading processing options was confirmed. The literature survey also served to define the on-site (at the turbine location) options for fuel treatment and exhaust gas ...
Amero, R. +3 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source