Results 51 to 60 of about 8,648,665 (313)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Callistemon viminalis 'Red Cascade': 'Red Cascade' Weeping Bottlebrush

EDIS, 2003
This popular evergreen tree has a dense, multitrunked, low-branching, pendulous growth habit and a moderate growth rate. Mature specimens can reach 25 to 30 feet tall in 30-years but most trees are seen 15 to 20 feet high and wide.
Edward Gilman, Dennis Watson
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Diffusion pump modification promotes self-cleansing and high efficiency [PDF]

, 1975
Modifications eliminate contaminant substances from pump fluid during operation, which are principal causes of torpidity on evaporative surface. Diffusion pump is also acting as still.
Buggele, A. E.
core   +1 more source

Constraining the Envelope Structure of L1527 IRS: Infrared Scattered Light Modeling

, 2008
We model Spitzer Space Telescope observations of the Taurus Class 0 protostar L1527 IRS (IRAS 04368+2557) to provide constraints on its protostellar envelope structure.
Calvet, Nuria, D'Alessio, Paola, Hartmann, Lee, Tobin, John J.   +3 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Roles of MPBQ-MT in Promoting α/γ-Tocopherol Production and Photosynthesis under High Light in Lettuce. [PDF]

PLoS ONE, 2016
2-methyl-6-phytyl-1, 4-benzoquinol methyltransferase (MPBQ-MT) is a vital enzyme catalyzing a key methylation step in both α/γ-tocopherol and plastoquinone biosynthetic pathway.
Yueli Tang, Xueqing Fu, Qian Shen, Kexuan Tang   +3 more
doaj   +1 more source

Observational Signature of High Spin at the Event Horizon Telescope

, 2018
We analytically compute the observational appearance of an isotropically emitting point source on a circular, equatorial orbit near the horizon of a rapidly spinning black hole.
Gralla, Samuel E., Lupsasca, Alexandru, Strominger, Andrew   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source