Results 41 to 50 of about 364,700 (260)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Light, Heat, and Force‐Responsive Polyolefins

Advanced Science
Stimuli‐responsive polymers have found applications as shape‐memory materials, optical switches, and sensors, but the installation of these responsive properties in non‐polar and inert polyolefins is challenging.
Weicheng Qu, Zhengxing Bi, Chen Zou, Changle Chen   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Light-responsive organic flashing electron ratchet [PDF]

Proceedings of the National Academy of Sciences, 2017
Significance Transport of objects in man-made systems typically relies on energy gradients that span the distance over which the particles must travel. Biological systems do not have these large-scale gradients available and instead transport particles with repeated local interactions between asymmetric structures, powered by nondirectional ...
Ofer, Kedem, Bryan, Lau, Mark A, Ratner, Emily A, Weiss   +3 more
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A multifunctional quasi-solid-state polymer electrolyte with highly selective ion highways for practical zinc ion batteries

Nature Communications
The uncontrolled dendrite growth and detrimental parasitic reactions of Zn anodes currently impede the large-scale implementation of aqueous zinc ion batteries.
Chengwu Yang, Pattaraporn Woottapanit, Sining Geng, Rungroj Chanajaree, Yue Shen, Kittima Lolupiman, Wanwisa Limphirat, Teerachote Pakornchote, Thiti Bovornratanaraks, Xinyu Zhang, Jiaqian Qin, Yunhui Huang   +11 more
doaj   +1 more source

Phenotyping of light-activated neurons in the mouse SCN based on the expression of FOS and EGR1

Frontiers in Physiology
Light-sensitive neurons are located in the ventral and central core of the suprachiasmatic nucleus (SCN), whereas stably oscillating clock neurons are found mainly in the dorsal shell.
Casper Schwartz Riedel, Birgitte Georg, Jens Hannibal   +2 more
doaj   +1 more source

The Arabidopsis Transcriptome Responds Specifically and Dynamically to High Light Stress

Cell Reports, 2019
Summary: The dynamic and specific transcriptome for high light (HL) stress in plants is poorly understood because heat has confounded previous studies.
Jianyan Huang, Xiaobo Zhao, Joanne Chory
doaj   +1 more source