Results 51 to 60 of about 364,700 (260)

Ce and Er Co-doped TiO2 for rapid bacteria- killing using visible light

Bioactive Materials, 2020
Bacterial infection and related diseases are threatening the health of human beings. Photocatalytic disinfection as a simple and low-cost disinfection strategy is attracting more and more attention. In this work, TiO2 nanoparticles (NPs) were modified by
Yawei Ren, Yajing Han, Zhaoyang Li, Xiangmei Liu, Shengli Zhu, Yanqin Liang, Kelvin Wai Kwok Yeung, Shuilin Wu   +7 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Light-Responsive and Dual-Targeting Liposomes: From Mechanisms to Targeting Strategies

Molecules
In recent years, nanocarriers have played an ever-increasing role in clinical and biomedical applications owing to their unique physicochemical properties and surface functionalities. Lately, much effort has been directed towards the development of smart,
Ahmed M. Agiba, José Luis Arreola-Ramírez, Verónica Carbajal, Patricia Segura-Medina   +3 more
doaj   +1 more source

Optically responsive delivery platforms: from the design considerations to biomedical applications

Nanophotonics, 2020
Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g.
Koryakina Irina, Kuznetsova Daria S., Zuev Dmitry A., Milichko Valentin A., Timin Alexander S., Zyuzin Mikhail V.   +5 more
doaj   +1 more source

Stimuli‐responsive active materials for dynamic control of light field

Responsive Materials, 2023
The increasing demand for the multidimensional and dynamic control of light has spurred the development of stimuli‐responsive, reconfigurable, and programmable optical systems.
Ren Zheng, Yang Wei, Zi‐Chen Zhang, Ze‐Yu Wang, Ling‐Ling Ma, Yu Wang, Ling Huang, Yan‐Qing Lu   +7 more
doaj   +1 more source

Light-responsive polymers for microfluidic applications [PDF]

Lab on a Chip, 2018
Light responsive polymers will drive revolutionary changes in microfluidics by reducing costs, platform dimensions and complexity.
Jeroen ter Schiphorst, Janire Saez, Dermot Diamond, Fernando Benito-Lopez, Albertus P. H. J. Schenning   +4 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Development of Visible Light-Responsive Sensitized Photocatalysts

International Journal of Photoenergy, 2012
The paper presents a review of studies about the visible-light-promoted photodegradation of the contaminants and energy conversion with sensitized photocatalysts.
Donghua Pei, Jingfei Luan
doaj   +1 more source

Light-Stimulated Hydrogels with Incorporated Graphene Oxide as Actuator Material for Flow Control in Microfluidic Applications

Proceedings, 2017
Temperature-responsive Poly-N-isopropylacrylamide (PNIPAAm) hydrogels were modified with graphene oxide (GO) nanoparticles to increase the light absorption significantly and these gels can be heated and stimulated optothermically.
Lars Breuer, Eric Guthmann, Michael J. Schöning, Ronald Thoelen, Torsten Wagner   +4 more
doaj   +1 more source