Results 91 to 100 of about 687,578 (301)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Light-mediated communication in responsive materials ranging from individual self-oscillators to feedback-driven network

Nature Communications
The natural interactive materials under far-from-equilibrium conditions have significantly inspired advances in synthetic biomimetic materials. In artificial systems, there are means of interaction between individuals, for instance, mechanical contact ...
Hongshuang Guo, Kai Li, Jianfeng Yang, Dengfeng Li, Fan Liu, Hao Zeng   +5 more
doaj   +1 more source

Research progress of environment-responsive hydrogel applications in agriculture

eXPRESS Polymer Letters
Environment-responsive hydrogels are environmentally friendly polymeric materials that rapidly respond to their environment by changing their volume or strength when the external environment, such as temperature, pH, light, and magnetism, changes.
Wenxu Zhang, Xuyang Mu, Yan Xu, Guofu Ma, Ziqiang Lei   +4 more
doaj   +1 more source

An all-photonic full color RGB system based on molecular photoswitches

Nature Communications, 2019
Stimuli-responsive multicolor luminescent materials typically react on external triggers of physical nature, but photonically controlled systems which allow for remote operation were not realized.
Gaowa Naren, Chien-Wei Hsu, Shiming Li, Masakazu Morimoto, Sicheng Tang, Jordi Hernando, Gonzalo Guirado, Masahiro Irie, Françisco M. Raymo, Henrik Sundén, Joakim Andréasson   +10 more
doaj   +1 more source

Molecular mechanisms driving the microgels behaviour: a Raman spectroscopy and Dynamic Light Scattering study

, 2019
Responsive microgels based on poly(N-isopropylacrylamide) (PNIPAM) exhibit peculiar behaviours due to the competition between the hydrophilic and hydrophobic interactions of the constituent networks. The interpenetration of poly-acrilic acid (PAAc), a pH-
Angelini, Roberta, Bertoldo, Monica, Buratti, Elena, Nigro, Valentina, Postorino, Paolo, Ripanti, Francesca, Ruzicka, Barbara, Sarra, Angelo   +7 more
core   +1 more source

ZINC-FINGER interactions mediate transcriptional regulation of hypocotyl growth in Arabidopsis [PDF]

, 2018
Integration of environmental signals and interactions among photoreceptors and transcriptional regulators is key in shaping plant development. TANDEM ZINC-FINGER PLUS3 (TZP) is an integrator of light and photoperiodic signaling that promotes flowering in
Breton, Ghislain, Chory, Joanne, Davidson, Mhairi L.H., Herzyk, Pawel, Kaiserli, Eirini, Kay, Steve A., Nastase, Ana-Maria, O'Donnell, Liz, Perrella, Giorgio, Pruneda-Paz, Jose L.   +9 more
core   +1 more source

Green Light-Responsive CO-Releasing Polymeric Materials Derived from Ring-Opening Metathesis Polymerization

ACS Applied Materials & Interfaces, 2019
Carbon monoxide (CO) is an important biological gasotransmitter in living cells. Precise spatial and temporal control over release of CO is a major requirement for clinical application. To date, the most reported carbon monoxide releasing materials use expensive fabrication methods and require harmful and poorly designed tissue-penetrating UV ...
Gandra, UR, Sinopoli, A, Moncho, S, Nandakumar, M, Ninković, DB, Zarić, SD, Sohail, M, Al-Meer, S, Brothers, EN, Mazloum, NA, Al-Hashimi, M, Bazzi, HS   +11 more
openaire   +7 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Editorial: Photochromic Materials: Design and Applications

Frontiers in Materials, 2021
Frederico B. De Sousa, Frank Alexis, Silvia Giordani   +2 more
doaj   +1 more source