Results 51 to 60 of about 687,578 (301)
Materials science and the sensor revolution [PDF]
, 2010 For the past decade, we have been investigating strategies to develop ways to provide chemical sensing platforms capable of long-term deployment in remote locations1-3.
Benito-Lopez, Fernando +2 more
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Bioinspired Multi‐Stimuli Responsive Actuators with Synergistic Color‐ and Morphing‐Change Abilities
Advanced Science, 2021 The combination of complex perception, defense, and camouflage mechanisms is a pivotal instinctive ability that equips organisms with survival advantages.
Xinkai Li +5 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Science and Technology of Advanced Materials, 2015 The grafting of poly(hydroxyethylmethacrylate) on polymeric porous membranes via atom transfer radical polymerization (ATRP) and subsequent modification with a photo-responsive spiropyran derivative is described.
Anja C Pauly +9 more
doaj +1 more source
Small Science, 2022 The electromagnetic (EM) devices have been widely used in communication, electrical engineering, and medical care. However, EM device is a double‐edged sword for its convenience is followed by signal pollution and radiation. Electromagnetic interference (
Yue Zhao +6 more
doaj +1 more source
Micro-patterning and actuation of phosphonium-based photo-responsive ionogels for micro-fluidic applications [PDF]
, 2011 The concept of “Micro-total-analysis-Systems” or “Lab-on-chip” has emerged over the past 20-years but, despite of the fact their incredible potential to revolutionise analytical science few outputs have reached the market so far[1].
Benito-Lopez, Fernando +3 more
core
Light-responsive paper strips as CO-releasing material with a colourimetric response
Chemical Science, 2017 A light-responsive paper strip as CO-releasing material (CORMA) for convenient and efficient CO-release with colorimetric response.
Upendar Reddy G. +9 more
openaire +3 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Drug-Loaded, Bivalent-Bottle-Brush Polymers by Graft-through ROMP [PDF]
, 2010 Graft through ring-opening metathesis polymerization (ROMP) using ruthenium N heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with unprecedented ease and control Here we report the first bivalent-brush polymers, these ...
Burts, Alan O. +6 more
core +1 more source