Results 71 to 80 of about 687,578 (301)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Integrated 3D Hydrogel Waveguide Out-Coupler by Step-and-Repeat Thermal Nanoimprint Lithography: A Promising Sensor Device for Water and pH [PDF]

, 2018
Hydrogel materials offer many advantages for chemical and biological sensoring due to their response to a small change in their environment with a related change in volume.
Bilbao, Leire, Delgado Simao, Claudia, Francone, Achille, Gadegaard, Nikolaj, Kehagias, Nikolaos, Kehoe, Timothy, Khokhar, Ali Z., Obieta, Isabel, Saez-Martinez, Virginia, Sotomayor Torres, Clivia M.   +9 more
core   +5 more sources

Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery [PDF]

Molecular Pharmaceutics, 2016
We describe, for the first time, stimulus-responsive hydrogel-forming microneedle (MN) arrays that enable delivery of a clinically relevant model drug (ibuprofen) upon application of light. MN arrays were prepared using a polymer prepared from 2-hydroxyethyl methacrylate (HEMA) and ethylene glycol dimethacrylate (EGDMA) by micromolding. The obtained MN
Hardy, John G., Larrañeta, Eneko, Donnelly, Ryan F., McGoldrick, Niamh, Migalska, Katarzyna, McCrudden, Maeliosa T.C., Irwin, Nicola J., Donnelly, Louise, McCoy, Colin P.   +8 more
openaire   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Photo-responsive functional materials based on light-driven molecular motors

Light: Science & Applications
In the past two decades, the research and development of light-triggered molecular machines have mainly focused on developing molecular devices at the nanoscale.
Yanping Deng, Guiying Long, Yang Zhang, Wei Zhao, Guofu Zhou, Ben L. Feringa, Jiawen Chen   +6 more
doaj   +1 more source

Photoreceptor System for Melatonin Regulation and Phototherapy [PDF]

, 2010
The present invention involves a light system for stimulating or regulating neuroendocrine, circadian, and photoneural systems in mammals based upon the discovery of peak sensitivity ranging from 425-505 nm; a light meter system for quantifying light ...
Brainard, George, Glickman, Gena
core   +1 more source

Characterization of Laser-Resistant Port Wine Stain Blood Vessels Using In Vivo Reflectance Confocal Microscopy. [PDF]

, 2019
Background and objectivesPort wine stain (PWS) is a congenital vascular malformation of the human skin. Laser is the treatment of choice for PWS. Laser-resistant PWS is one crucial factor accounting for inadequate treatment outcome, which needs to be ...
Chen, Jing, Fu, Zhibing, Huang, Jian, Huang, Jinhua, Lu, Jianyun, Nelson, J Stuart, Tan, Wenbin, Tang, Zhen, Xiang, Yaping   +8 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Modification of TiO_2 Nanoparticles with Organodiboron Molecules Inducing Stable Surface Ti^(3+) Complex [PDF]

, 2019
As one of the most promising semiconductor oxide materials, titanium dioxide (TiO_2) absorbs ultraviolet (UV) light but not visible light. To address this limitation, the introduction of Ti^(3+) defects represents a common strategy to render TiO_2 ...
Azad, Aryan, Cao, Yang, Dong, Bo-Wei, Guo, Shaojun, Jiang, Shang-Da, Liu, Zheng, Ma, Dongge, Ma, Wanhong, Mo, Fanyang, Tu, Yongguang, Wang, Dong, Yang, Yang, Zhang, Xu, Zhou, Peng, Zhu, Rui   +14 more
core   +1 more source

Electrostatically gated membrane permeability in inorganic protocells [PDF]

, 2013
Although several strategies are now available to produce functional microcompartments analogous to primitive cell-like structures, little progress has been made in generating protocell constructs with self-controlled membrane permeability.
A Boker, A Dzieciol, A Pohorille, AB Subramaniam, AB Subramaniam, AD Dinsmore, B Städler, Bernard P. Binks, C Wu, D Lee, DS Williams, DY Wang, GJT Cooper, J-W Kim, Jonathan V. M. Weaver, JVM Weaver, JW Szostak, KL Thompson, M Li, Mei Li, MF Hsu, P Stano, P Stano, P Walde, Rachel L. Harbron, RK Shah, RL Harbron, S Koga, S Mann, Stephen Mann, W Martin   +30 more
core   +4 more sources