Results 81 to 90 of about 687,578 (301)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

One-Step Generation of Multifunctional Polyelectrolyte Microcapsules via Nanoscale Interfacial Complexation in Emulsion (NICE) [PDF]

Polyelectrolyte microcapsules represent versatile stimuli-responsive structures that enable the encapsulation, protection, and release of active agents.
Burdick, JA, Doh, J, Highley, CB, Kim, M, Lee, D, Yeo, SJ, Yoo, PJ   +6 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multimodal Platforms for Light‐Mediated Organic Bioelectronics

Advanced Materials Interfaces
The development of bioelectronic devices has significantly advanced the field of clinical diagnosis and therapy. Recent progress in light technology has attracted considerable attention as a promising approach for wireless modulation of biological ...
Giovanna Gentile, Mehdi Ravandeh, Luisa Petti, Francesca D'Elia, Francesca Santoro   +4 more
doaj   +1 more source

Reversible end-to-end assembly of selectively functionalized gold nanorods by light-responsive arylazopyrazole–cyclodextrin interaction

Beilstein Journal of Organic Chemistry, 2019
We propose a two-step ligand exchange for the selective end-functionalization of gold nanorods (AuNR) by thiolated cyclodextrin (CD) host molecules. As a result of the complete removal of the precursor capping agent cetyltrimethylammonium bromide (CTAB ...
Maximilian Niehues, Patricia Tegeder, Bart Jan Ravoo   +2 more
doaj   +1 more source

Structured Optical Materials Controlled by Light [PDF]

, 2018
Materials of which the optical response is determined by their structure are of much interest both for their fundamental properties and applications. Examples range from simple gratings to photonic crystals.
Martella, Daniele, Nocentini, Sara, Parmeggiani, Camilla, Wiersma, Diederik S., Zanotto, Simone   +4 more
core   +3 more sources

Light-responsive Materials for Microfluidic Applications

, 2018
While the microfluidic device itself may be small, often the equipment required to control fluidics in thechip unit is large e.g. pumps, valves and mixing units, which can severely limit practical use and functionalscalability. In addition, components associated with fluidic control of the device, more specifically thevalves and pumps, contribute ...
Ter Schiphorst, Jeroen, Sáez Castaño, Janire, Diamond, Dermot, Benito López, Fernando, Schenning, Albertus P. H. J.   +4 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Azo dye polyelectrolyte multilayer films reversibly re-soluble with visible light

Frontiers in Materials
Polymeric multilayer films were prepared using a layer-by-layer (LBL) technique on glass surfaces, by repeated and sequential dipping into dilute aqueous solutions of various combinations of water-soluble polyanions (polyacrylic acid (PAA)), polycations (
Mikhail Kim, Coral Hillel, Kayrel Edwards, Tristan H. Borchers, Ozzy Mermut, Ozzy Mermut, Ozzy Mermut, William J. Pietro, Christopher J. Barrett, Christopher J. Barrett   +9 more
doaj   +1 more source