Results 121 to 130 of about 2,321,585 (305)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Kilonova light-curve interpolation with neural networks

Physical Review Research
Kilonovae are the electromagnetic transients created by the radioactive decay of freshly synthesized elements in the environment surrounding a neutron star merger. To study the fundamental physics in these complex environments, kilonova modeling requires,
Yinglei Peng, Marko Ristić, Atul Kedia, Richard O'Shaughnessy, Christopher J. Fontes, Chris L. Fryer, Oleg Korobkin, Matthew R. Mumpower, V. Ashley Villar, Ryan T. Wollaeger   +9 more
doaj   +1 more source

The Optical SN 2012bz Associated with the Long GRB 120422A

, 2012
The association of Type Ic SNe with long-duration GRBs is well established. We endeavor, through accurate ground-based observational campaigns, to characterize these SNe at increasingly high redshifts.
A. J. Castro-Tirado, A. Melandri, A. V. Filippenko, Amati, Amati, Amati, Band, Berger, Bernardini, Bersier, Bloom, Bufano, C. Guidorzi, C. Kouveliotou, Cano, Cano, Cardelli, Cobb, Corsi, D. Bersier, D. Fugazza, Della Valle, Della Valle, Della Valle, Della Valle, Deng, Deng, E. Palazzi, E. Pian, E. S. Walker, F. Bufano, F. Patat, Ferrero, Filippenko, Fukugita, Fynbo, G. Chincarini, G. Ghirlanda, G. Ghisellini, G. Marconi, G. Tagliaferri, Gal-Yam, Gal-Yam, Galama, Galama, Garnavich, Ghisellini, Gorosabel, Greiner, Guetta, Hjorth, I. Saviane, Iwamoto, J. Deng, K. Maeda, K. Nomoto, Kaneko, L. A. Antonelli, L. Amati, Lazzati, Li, Lipkin, M. Della Valle, M. G. Bernardini, M. Tanaka, MacFadyen, Malesani, Masetti, Matheson, Mazzali, Mazzali, Mazzali, Mazzali, Mazzali, Mirabal, Modjaz, N. Masetti, Nakamura, P. A. Mazzali, P. D’Avanzo, P. Ferrero, Paczyński, Patat, Pian, Pignata, Podsiadlowski, R. L. C. Starling, R. Salvaterra, Ramirez-Ruiz, S. Campana, S. Covino, S. D. Vergani, S. Piranomonte, Sauer, Schlegel, Soderberg, Soderberg, Soderberg, Soderberg, Sollerman, Sparre, Stanek, Starling, Taubenberger, V. D’Elia, Vanderspek, Woosley, Zhang   +107 more
core   +2 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Identifying Light-curve Signals with a Deep-learning-based Object Detection Algorithm. II. A General Light-curve Classification Framework

The Astrophysical Journal Supplement Series
Vast amounts of astronomical photometric data are generated from various projects, requiring significant effort to identify variable stars and other object classes.
Kaiming Cui, D. J. Armstrong, Fabo Feng
doaj   +1 more source

Variable stars in the residual light curves of OGLE-IV eclipsing binaries towards the Galactic Bulge [PDF]

, 2023
Rozália Z. Ádám, T. Hajdu, Attila Bódi, Róbert Hajdu, T. Szklenár, L. Molnár   +5 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Explanation of Light Deflection, Precession of Mercury’s Perihelion, Gravitational Red Shift and Rotation Curves in Galaxies, by using General Relativity or equivalent Generalized Scalar Gravitational Potential, according to Special Relativity and Newtonian Physics

, 2021
Spyridon Vossos, Elias Vossos, Christos G. Massouros   +2 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

SN2017ein: bolometric light curve and physical parameters

Physical Sciences and Technology, 2018
Apparent stellar magnitudes observed at Maidanak observatory for SN2017ein – peculiarly faint core-collapse supernova rumored to have images of progenitor – are processed to get exact photometric data.
P.S. Tadjimuratov, D. Mirzakulov
doaj