Results 131 to 140 of about 7,751,768 (367)

COSMOLOGICAL PARAMETER UNCERTAINTIES FROM SALT-II TYPE IA SUPERNOVA LIGHT CURVE MODELS [PDF]

open access: yes, 2014
We use simulated type Ia supernova (SN Ia) samples, including both photometry and spectra, to perform the first direct validation of cosmology analysis using the SALT-II light curve model.
J. Mosher   +15 more
semanticscholar   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Reliable inference of exoplanet light-curve parameters using deterministic and stochastic systematics models [PDF]

open access: yes, 2014
Time-series photometry and spectroscopy of transiting exoplanets allow us to study their atmospheres. Unfortunately, the required precision to extract atmospheric information surpasses the design specifications of most general purpose instrumentation ...
N. Gibson
semanticscholar   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

Photometrical observations and shape modeling of space debris in medium Earth orbits

open access: yesSolar-Terrestrial Physics
The circular medium Earth orbits with a period of about half a day in the inclination range from 50° to 70° are used by various global navigation satellite systems (GNSS), such as GLONASS, GPS, Beidou, Galileo.
Korobtsev I. V.   +4 more
doaj   +1 more source

On the nature of rapidly fading Type II supernovae

open access: yes, 2015
It has been suggested that Type II supernovae with rapidly fading light curves (a.k.a. Type IIL supernovae) are explosions of progenitors with low-mass hydrogen-rich envelopes which are of the order of 1 Msun.
Blinnikov, Sergei I.   +3 more
core   +1 more source

Light-Curve Modelling Constraints on the Obliquities and Aspect Angles of the Young Fermi Pulsars [PDF]

open access: yes, 2014
In more than four years of observation the Large Area Telescope on board the Fermi satellite has identified pulsed γ-ray emission from more than 80 young or middle-aged pulsars, in most cases providing light curves with high statistics.
M. Pierbattista   +9 more
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu   +15 more
wiley   +1 more source

New NIR light-curve templates for classical Cepheids [PDF]

open access: yes, 2014
Aims. We present new near-infrared (NIR) light-curve templates for fundamental (FU, J, H, KS) and first overtone (FO, J) classical Cepheids. The new templates together with period-luminosity and period-Wesenheit (PW) relations provide Cepheid distances ...
L. Inno   +63 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

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