Results 141 to 150 of about 2,354,988 (346)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Kilonova light-curve interpolation with neural networks

Physical Review Research
Kilonovae are the electromagnetic transients created by the radioactive decay of freshly synthesized elements in the environment surrounding a neutron star merger. To study the fundamental physics in these complex environments, kilonova modeling requires,
Yinglei Peng, Marko Ristić, Atul Kedia, Richard O'Shaughnessy, Christopher J. Fontes, Chris L. Fryer, Oleg Korobkin, Matthew R. Mumpower, V. Ashley Villar, Ryan T. Wollaeger   +9 more
doaj   +1 more source

The I/T curve coefficient for evaluating changes in neuromuscular excitability after polarized light irradiation - a placebo-controlled randomized trial

, 2020
Jolanta Zwolińska
openalex   +1 more source

Asymmetric light curves of the contact binary AB Andromedae [PDF]

, 1984
S. A. Bell, R. W. Hilditch, David King
openalex   +1 more source

Simulated optical light curves of super-Eddington tidal disruption events with ZEBRA flows [PDF]

, 2022
R. A. J. Eyles-Ferris, R. Starling, P. T. O’Brien, C. J. Nixon, Eric R. Coughlin   +4 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Identifying Light-curve Signals with a Deep-learning-based Object Detection Algorithm. II. A General Light-curve Classification Framework

The Astrophysical Journal Supplement Series
Vast amounts of astronomical photometric data are generated from various projects, requiring significant effort to identify variable stars and other object classes.
Kaiming Cui, D. J. Armstrong, Fabo Feng
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Breaking the Degeneracy in Magnetic Cataclysmic Variable X-Ray Spectral Modeling Using X-Ray Light Curves [PDF]

, 2021
Diogo Belloni, C. V. Rodrigues, M. R. Schreiber, Manuel Castro, J. E. R. Costa, Takayuki Hayashi, I. J. Lima, G. J. M. Luna, Murilo Martins, A. S. Oliveira, S. G. Parsons, K. M. G. Silva, Paulo E. Stecchini, T. J. Stuchi, M. Zorotovic   +14 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source