Results 91 to 100 of about 5,923,968 (244)

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

TTC: Transformer-based TDE Classifier for the Wide Field Survey Telescope (WFST)

The Astrophysical Journal
We propose the Transformer-based Tidal disruption events (TDE) Classifier ( TTC ), specifically designed to operate effectively with both real-time alert streams and archival data of the Wide Field Survey Telescope (WFST).
Ranfang Zheng, Zheyu Lin, Xu Kong, Dezheng Meng, Zelin Xu, Lulu Fan, Ji-an Jiang, Ning Jiang, Jie Lin, Tinggui Wang, Qingfeng Zhu, Feng Li, Ming Liang, Hao Liu, Zheng Lou, Wentao Luo, Jinlong Tang, Hairen Wang, Jian Wang, Yongquan Xue, Dazhi Yao, Hong-fei Zhang, Wen Zhao, Xianzhong Zheng, Yingxi Zuo   +24 more
doaj   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Reframing Variable Star Classification as Structured Sequence Modeling with Large Language Models

The Astrophysical Journal
Variable stars play a crucial role in advancing knowledge of stellar evolution, Galactic structure, and cosmological distance scales. The advent of massive datasets from modern time-domain surveys (e.g., Zwicky Transient Facility, All-Sky Automated ...
Zeguang Shao, Ce Yu, Bin Yang, Xiaodian Chen   +3 more
doaj   +1 more source

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

Classification performance assessment for imbalanced multiclass data

Scientific Reports
The evaluation of diagnostic systems is pivotal for ensuring the deployment of high-quality solutions, especially given the pronounced context-sensitivity of certain systems, particularly in fields such as biomedicine.
Jesús S. Aguilar-Ruiz, Marcin Michalak
doaj   +1 more source

Phillips Curve or wage curve? : evidence from West Germany: 1980-2004 [PDF]

"This paper reconsiders the West German wage curve using the employment statistics of the Federal Employment Services of Germany (Bundesanstalt für Arbeit) over the period 1980-2004.
Blien, Uwe, Wolf, Katja, Baltagi, Badi H.   +2 more
core  

Impact of Age on the Diagnostic Yield of Routine EEG in People With Childhood or Juvenile Absence Epilepsy: A Cross‐Sectional Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background We aimed to identify the proportion of individuals with a confirmed diagnosis of childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE) who show a negative routine EEG (rEEG), and to determine the main factors associated with this finding.
Francesco Fortunato, Alessia Giugno, Miriam Sturniolo, Enrico Fratto, Pio Zoleo, Francesca Felicia Operto, Ilaria Sammarra, Antonio Gambardella   +7 more
wiley   +1 more source

NAPTIME: A Neural-process Framework for Rubin Alert Classification

The Astrophysical Journal
The Vera C. Rubin Observatory Legacy Survey of Space and Time will produce a high-volume stream of irregularly sampled multiband alerts for which spectroscopic confirmation will be available only for a small minority of sources.
Nicholas Earl, Siddharth Chaini, K. Decker French, Jason T. Hinkle, Yashasvi Moon, Margaret Shepherd   +5 more
doaj   +1 more source