Results 91 to 100 of about 1,606,955 (297)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Tailored topotactic chemistry unlocks heterostructures of magnetic intercalation compounds

open access: yesNature Communications
The construction of thin film heterostructures has been a widely successful archetype for fabricating materials with emergent physical properties. This strategy is of particular importance for the design of multilayer magnetic architectures in which ...
Samra Husremović   +18 more
doaj   +1 more source

Live imaging of alveologenesis in precision-cut lung slices reveals dynamic epithelial cell behaviour

open access: yesNature Communications, 2019
The process of alveologenesis is incompletely understood, partly due to the lack of applicable real-time imaging methods. Here the authors describe the process of alveologenesis and the behaviour of epithelial cells in real-time, using widefield ...
Khondoker M. Akram   +8 more
doaj   +1 more source

Light microscopy - Methods and protocols

open access: yesEuropean Journal of Histochemistry, 2011
The first part of the book (six chapters) is devoted to some selected applications of bright-field microscopy while the second part (eight chapters) to some fluorescence microscopy studies.
CarloAlberto Redi
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Milestones in light microscopy [PDF]

open access: yesNature Cell Biology, 2009
A supplement contextualizes key advances in light microscopy over 400 years, while the Tara expedition sets sail to explore oceanic ecosystems at the microscopic level.
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

The role of light microscopy in aerospace analytical laboratories [PDF]

open access: yes
Light microscopy has greatly reduced analytical flow time and added new dimensions to laboratory capability. Aerospace analytical laboratories are often confronted with problems involving contamination, wear, or material inhomogeneity.
Crutcher, E. R.
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Correlating light and electron microscopy

open access: yesBioTechniques, 2014
Correlating the molecular specificity of light microscopy with the high structural resolution of electron microscopy can be a challenge. Jeffrey Perkel looks at the ways researchers are bringing together these methods—and the wondrous cellular details ...
Jeffrey M. Perkel
doaj   +1 more source

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