Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Study of timing characteristics of a 3 m long plastic scintillator counter using waveform digitizers
, 2016 A plastic scintillator bar with dimensions 300 cm x 2.5 cm x 11 cm was exposed to a focused muon beam to study its light yield and timing characteristics as a function of position and angle of incidence.
A. Blondel +22 more
core +3 more sources
Light yield measurement method for milled nanosize inorganic crystals
Applied Radiation and Isotopes, 2012 Composite scintillators consisting of nanosize inorganic crystals embedded in an organic matrix have been actively pursued in recent years. One method of producing nanosize crystals is through wet milling; however, since milling is known to introduce defects, the light yield of the milled crystals must be characterized.
Andy, Li +4 more
openaire +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Lattice Expansion in Rb-Doped Hybrid Organic-Inorganic Perovskite Crystals Resulting in Smaller Band-Gap and Higher Light-Yield Scintillators. [PDF]
Inorg Chem, 2023 Maddalena F +11 more
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Ytterbium-Doped Cesium Lead Chloride Perovskite as an X-ray Scintillator with High Light Yield. [PDF]
ACS Omega, 2022 Dagnall KA +5 more
europepmc +1 more source
Intermittent flow in yield-stress fluids slows down chaotic mixing
, 2013 In this article, we present experimental results of chaotic mixing of Newtonian uids and yield stress fluids using rod-stirring protocol with rotating vessel.
Gouillart, Emmanuelle +3 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Far-Red Light Inhibits Soybean Biomass and Yield by Modulating Plant Photosynthesis
AgronomyAlterations in the light environment can significantly influence soybean morphology and yield formation; however, the effects and mechanisms of different light qualities on these aspects require further investigation.
Qiangui Wang +5 more
doaj +1 more source