Results 51 to 60 of about 7,068 (173)

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Orbiter CCTV video signal noise analysis [PDF]

The amount of steady state and transient noise which will couple to orbiter CCTV video signal wiring is predicted. The primary emphasis is on the interim system, however, some predictions are made concerning the operational system wiring in the cabin ...
Blanke, L. R., Lawton, R. M., Pannett, R. F.   +2 more
core   +1 more source

Unraveling in vitro phase separation and aggregation properties of the structured region of FMRP and the impact of Fragile X syndrome‐linked mutations

The FEBS Journal, EarlyView.
Fragile X messenger ribonucleoprotein 1 (FMRP) is a multidomain RNA‐binding protein associated with Fragile X Syndrome (FXS). We found that its N‐terminal structured region has an intrinsic propensity to undergo liquid–liquid phase separation and fibril formation. FXS‐associated mutations perturb protein stability and aggregation propensity, suggesting
Flavia Catalano, Alessandra Bigi, Francesca Troilo, Federica Gabriele, Gianluca Pistoia, Italia A. Asteriti, Francesco Angelucci, Giorgio Giardina, Fabrizio Chiti, Carlo Travaglini‐Allocatelli, Adele Di Matteo   +10 more
wiley   +1 more source

Space shuttle lightning protection criteria document [PDF]

The lightning environment for design is defined and imposes the requirements that the design must satisfy to insure the protection of the space shuttle vehicle system from the direct and indirect effects of lightning.

core   +1 more source

Two Faces of the Anti‐Inclusion Neoconservative Coin in Brazil: Neoliberalism and Far‐Right

Gender, Work &Organization, EarlyView.
ABSTRACT Brazil has recently experienced the resurgence of the far‐right, a movement that has also occurred in other countries around the world. Given this context, this article seeks to understand the factors that enabled the union among neoliberalism, neoconservatism, and the far‐right in Brazil, demonstrating that in times of economic crisis the ...
Eloisio Moulin de Souza
wiley   +1 more source

Quality Regulation and Unexpected Gaming: Evidence From Mandating Flight Delay Compensation

Journal of Economics &Management Strategy, EarlyView.
ABSTRACT Policies that target a single aspect of agents' motivation may lead to their diminished efforts in other areas. This paper examines the effect of the European Union's flight delay compensation policy on flight on‐time performance by exploiting a unique policy variation in a difference‐in‐differences framework.
Jingyi Xing
wiley   +1 more source

Axial muscle‐fibre orientations in larval zebrafish

Journal of Anatomy, Volume 246, Issue 4, Page 517-533, April 2025.
In 4 days post‐fertilization zebrafish larvae, the fast axial muscle fibres follow helical trajectories that taper towards the tail. Adjacent muscle fibres form substantial angles relative to each other to accommodate this pattern. Using a novel semi‐automatic method, we quantified 3D fibre angles over the whole muscle volume.
Noraly M. M. E. van Meer, Johan L. van Leeuwen, Henk Schipper, Martin J. Lankheet   +3 more
wiley   +1 more source

Shaping future forests: how can ecophysiology support climate‐smart forest management?

New Phytologist, EarlyView.
Summary Climate change, particularly the associated increase in extreme events and disturbances, threatens the numerous environmental, social, and economic benefits that forests provide, both locally and globally. Heat and drought pose significant risks to forest ecosystems; the anticipated future climate is expected to exacerbate this trend ...
Arthur Gessler, José M. Grünzweig, Laura Bigio, Henrik Hartmann, Nate McDowell, Frank Krumm, Arun K. Bose, Andreas Rigling, Harald Bugmann, Valentina Vitali, Pascal Schneider, J. Jelle Lever, Janine Schweier, Anne Kempel, Niklaus E. Zimmermann, Philipp Brun, Jürgen Bauhus, Micah Wilhelm, Alessandra Bottero   +18 more
wiley   +1 more source

A High‐Throughput Phenotyping Pipeline for Quinoa (Chenopodium quinoa) Panicles Using Image Analysis With Convolutional Neural Networks

Plant Breeding, EarlyView.
ABSTRACT Quinoa is a grain crop with excellent nutritional properties that has attracted global attention for its potential contribution to future food security in a changing climate. Despite its long history of cultivation, quinoa has been improved little by modern breeding and is a niche crop outside its native cultivation area.
Flavio Lozano‐Isla, Lydia Kienbaum, Bettina I. G. Haussmann, Karl Schmid   +3 more
wiley   +1 more source

Laws and Reasons Why

Analytic Philosophy, EarlyView.
ABSTRACT Laws play some role in explanations: at the very least, they somehow connect what is explained, or the explanandum, to what explains, or the explanans. Thus, thermodynamical laws connect the match's being struck and its lightning, so that the former causes the latter; and laws about set formation connect Socrates' existence with {Socrates}'s ...
Julio De Rizzo
wiley   +1 more source