Results 41 to 50 of about 3,012,816 (257)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Assigning the causative lightning to the whistlers observed on satellites [PDF]

Annales Geophysicae, 2006
We study the penetration of lightning induced whistler waves through the ionosphere by investigating the correspondence between the whistlers observed on the DEMETER and MAGION-5 satellites and the lightning discharges detected by the European ...
J. Chum, F. Jiricek, O. Santolik, O. Santolik, M. Parrot, G. Diendorfer, J. Fiser   +6 more
doaj   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Comparison of Lightning Detection Between the FY‐4A Lightning Mapping Imager and the ISS Lightning Imaging Sensor

Earth and Space Science, 2021
The Lightning Mapping Imager (LMI) onboard Fengyun‐4A (FY‐4A) is the first Chinese lightning detection sensor in geostationary orbit. This study presents the lightning characteristics observed by the FY‐4A LMI in its first year, and then observations ...
Xiang Ni, Wen Hui, Qinghong Zhang, Fuxiang Huang, Chuntao Liu   +4 more
doaj   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

New Method for Single-Site Cloud-to-Ground Lightning Location Based on Tri-Pre Processing

Remote Sensing
The single-site lightning detection system can provide timely and effective information on lightning activity in areas where a multi-site lightning network cannot be built.
Bingzhe Dai, Qilin Zhang, Jie Li, Yi Liu, Minhong Zhao   +4 more
doaj   +1 more source

Phillip Lightning interview

, 1975
8 p. transcript of an interview with Phillip Lightning conducted by Richard Lightning on April 11, 1975. Tape number IH-191, transcript disc 38.Tells stories from his father and grandfather of the signing of Treaty #6 and of Indian life before that time ...
Lightning, Richard, Lightning, Phillip
core   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

Lightning Location Systems and Interstroke Intervals: Effects of Imperfect Detection Efficiency

, 2016
Lightning location systems (LLSs) are often used to obtain parameters of lightning flashes. However, the imperfect detection efficiency (DE) of these systems affects the accuracy of the results.
Rachidi, Farhad, Azadifar, Mohammad, Rubinstein, Marcos, Stolijovic, Mirjana, Farhad Rachidi, Stojilovic, Mirjana, Mirjana Stojilovic, Marcos Rubinstein, Mohammad Azadifar   +8 more
core   +2 more sources

Enhanced Acoustic Adhesion Enabling Agile and Small Wall‐Climbing Robot Design With Anisotropic Origami Structure

Advanced Science, EarlyView.
This 28 g robot incorporates innovative ring structures and anisotropic origami springs to achieve high speeds and exceptional load capacity. It successfully carries a 100 g payload while ascending walls or ceilings at speeds of up to 8 and 20 cm/s, demonstrating enhanced adhesion and maneuverability over current climbing robots.
Xinxian Chen, Kanglong Yuan, Ao Qin, Yikun Liu, Yusen Ma, Jun Peng   +5 more
wiley   +1 more source