Results 51 to 60 of about 18,553,187 (294)
Advanced Science, EarlyView.This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo +17 more
wiley +1 more source
Advanced Science, EarlyView.MolDBG is a site‐aware, sequence‐only framework that unifies drug‐target affinity prediction, binding‐site identification, and affinity‐conditioned molecular generation for structured proteins. Guided by multi‐task binding‐site supervision, it aligns interaction‐critical residues before learning drug‐target representations and simultaneously infers ...
Gang Luo +6 more
wiley +1 more source
Advanced Science, EarlyView.This study elucidates the microstructural evolution at the material interface of Ni‐plated plain‐weave carbon fiber fabric following vacuum heat treatment at 500°C–900°C under different current densities, as well as the mechanism underlying the synergistic enhancement of electromagnetic shielding and ductility.
Wei Cheng +7 more
wiley +1 more source
Application of BeiDou RNSS timing technology in smart grid lightning locating system
Dianxin kexue, 2019 The smart grid lightning location system is an important power service,and its lightning location accuracy largely depends on the accuracy of time synchronization.Three kinds of BeiDou timing methods were studied and compared,and the RNSS timing method ...
Hao ZHANG +3 more
doaj +2 more sources
Lightning faults of DC dry-type air-core reactor in HVDC substation
Energy Reports, 2022 Dry-type air-core reactors of DC filter are important Equipments in HVDC converter stations. Four abnormal noises occurred in the pole II DC filter field of a ± 800kV converter station of china in 2020.
Xiao Lei +3 more
doaj +1 more source
A fractal model for the lightning induced current on a transmission line [PDF]
, 1997 This article presents a model of a tortuous lightning channel, and a study of the consequent electromagnetic coupling to a transmission line. We analyse the fractal dimension of the induced current on the line, compared with the fractal dimension of the ...
Vecchi, Giuseppe +6 more
core +1 more source
Advanced Science, EarlyView.The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English +9 more
wiley +1 more source
Application of the 2σ Lightning Jump Algorithm Based on DBSCAN Cluster
应用气象学报, 2023 A DBSCAN (density-based spatial clustering of applications with noise) cluster of lightning data is proposed as the substitute for radar products to solve the problem of beam blockage in radar observation and the delay of radar products in service ...
Tian Ye +8 more
doaj +1 more source
Advanced Science, EarlyView.Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai +12 more
wiley +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source