Results 51 to 60 of about 19,525,180 (293)

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Development of the lightning location mapping system using fuzzy logic technique [PDF]

, 2011
The extremely high current produced from the lightning strike causes damages to the structures and fatalities to the human and live stock. Information regarding the lightning strikes and the location where it strikes is very useful for the utilities and ...
Ab Kadir, Mohd Zainal Abidin, Che Soh, Azura, Abdul Rahman, Ribhan Zafira, Mohd Shif, Nor Shazana   +3 more
core   +1 more source

Lightning faults of DC dry-type air-core reactor in HVDC substation

Energy Reports, 2022
Dry-type air-core reactors of DC filter are important Equipments in HVDC converter stations. Four abnormal noises occurred in the pole II DC filter field of a ± 800kV converter station of china in 2020.
Xiao Lei, Jingyao Xu, Bo Feng, Shengqing Chen   +3 more
doaj   +1 more source

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Application of the 2σ Lightning Jump Algorithm Based on DBSCAN Cluster

应用气象学报, 2023
A DBSCAN (density-based spatial clustering of applications with noise) cluster of lightning data is proposed as the substitute for radar products to solve the problem of beam blockage in radar observation and the delay of radar products in service ...
Tian Ye, Pang Wenjing, Chen Zefang, He Na, Zhao Sen, Ji Yan, Hao Rui, Zhang Tianming, Yan Di   +8 more
doaj   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

PLOD1 Catalytic Activity Stabilizes ENO1 by Limiting FBXW7‐dependent Degradation to Promote Glycolysis and TMZ Resistance in Glioblastoma

Advanced Science, EarlyView.
PLOD1 interacts with ENO1 and limits its FBXW7‐dependent ubiquitination and proteasomal degradation through a mechanism requiring PLOD1 catalytic activity. ENO1 stabilization sustains glycolysis, promoting glioblastoma cell proliferation, migration, and temozolomide resistance.
Fen Xue, Dingkong Liang, Xin Chen, Fei Fan, Xiayun He   +4 more
wiley   +1 more source

The Foshan Total Lightning Location System in China and Its Initial Operation Results

Atmosphere, 2019
In the summer of 2013, a three-dimensional (3D)-based Foshan Total Lightning Location System (FTLLS), embedded with differential time of arrival (DTOA) techniques, was installed and started its operation in Foshan, Guangdong Province, China.
Li Cai, Xin Zou, Jianguo Wang, Quanxin Li, Mi Zhou, Yadong Fan   +5 more
doaj   +1 more source

Kalman Filter and Wavelet Cross-Correlation for VHF Broadband Interferometer Lightning Mapping

Applied Sciences, 2020
Lightning mapping systems based on perpendicular crossed baseline interferometer (ITF) technology have been developed rapidly in recent years. Several processing methods have been proposed to estimate the temporal location and spatial map of lightning ...
Ammar Alammari, Ammar A. Alkahtani, Mohd Riduan Ahmad, Fuad Noman, Mona Riza Mohd Esa, Muhammad Haziq Mohammad Sabri, Sulaiman Ali Mohammad, Ahmed Salih Al-Khaleefa, Zen Kawasaki, Vassilios Agelidis   +9 more
doaj   +1 more source

Enhanced Acoustic Adhesion Enabling Agile and Small Wall‐Climbing Robot Design With Anisotropic Origami Structure

Advanced Science, EarlyView.
This 28 g robot incorporates innovative ring structures and anisotropic origami springs to achieve high speeds and exceptional load capacity. It successfully carries a 100 g payload while ascending walls or ceilings at speeds of up to 8 and 20 cm/s, demonstrating enhanced adhesion and maneuverability over current climbing robots.
Xinxian Chen, Kanglong Yuan, Ao Qin, Yikun Liu, Yusen Ma, Jun Peng   +5 more
wiley   +1 more source