Results 211 to 220 of about 1,540,370 (339)

Automatic forward model parameterization with Bayesian inference of conformational populations. [PDF]

APL Mach Learn
Raddi RM, Marshall T, Voelz VA.
europepmc   +1 more source

Empirical likelihood methods based on influence functions [PDF]

, 2012
Wen Yu, Ziqiang Zhao, Ming Zheng
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Time-constant absolute effect measures for time-to-event outcomes. [PDF]

BMC Med Res Methodol
Kuss O, Hoyer A.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Bayesian Estimation of Multicomponent Stress-Strength Model Using Progressively Censored Data from the Inverse Rayleigh Distribution. [PDF]

Entropy (Basel)
Yılmaz A.
europepmc   +1 more source

Likelihood functions for stochastic signals in white noise

, 1970
Tyrone E. Duncan
openalex   +2 more sources

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Reliability analysis of inverted exponentiated Rayleigh parameters via progressive hybrid censoring data with applications in medical data. [PDF]

PLoS One
Nassr SG, Abo-Kasem OE, Khashab RH, Alshawarbeh E, Alshqaq SS, Elharoun NM.   +5 more
europepmc   +1 more source

estimating the survival function Maximum Likelihood and Cramér-Von Mises Method use of amixture distribution weibull and ailamujia with apractical application

Azraa Jafaar, Wafa Jafaar
openalex   +2 more sources