Results 141 to 150 of about 3,536,755 (285)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

On the Existence of the Moments of the Asymptotic Trace Statistic [PDF]

In this note we establish the existence of the first two moments of the asymptotic trace statistic, which appears as weak limit of the likelihood ratio statistic for testing the cointe- gration rank in a vector autoregressive model and whose moments may ...
Deniz Dilan Karaman Örsal, Bernd Droge
core  

Tests and Confidence Intervals for an Extended Variance Component Using the Modified Likelihood Ratio Statistic

The large deviation modified likelihood ratio statistic is studied for testing a variance component equal to a specified value. Formulas are presented in the general balanced case, whereas in the unbalanced case only the one-way random effects model is ...
JENS L. JENSEN, OLE F. CHRISTENSEN, MORTEN FRYDENBERG, JØRGEN G. PEDERSEN   +3 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Reduce computation in profile empirical likelihood method [PDF]

Since its introduction by Owen in [29, 30], the empirical likelihood method has been extensively investigated and widely used to construct confidence regions and to test hypotheses in the literature.
Peng, Liang, Li, Minqiang, Qi, Yongcheng
core  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

UNA COMPARACIÓN ENTRE LA INFERENCIA BASADA EN LAS ESTADÍSTICAS DE WALD Y RAZÓN DE VEROSIMILITUD EN LOS MODELOS LOGIT Y PROBIT VÍA MONTE CARLO UNA COMPARACIÓN ENTRE LA INFERENCIA BASADA EN LAS ESTADÍSTICAS DE WALD Y RAZÓN DE VEROSIMILITUD EN LOS MODELOS LOGIT Y PROBIT VÍA MONTE CARLO

Revista Colombiana de Estadística, 2005
In this paper we present a study which evaluates and compares the performance of hypothesis testing and confidence intervals based on Wald’s statistic with those based on the likelihood ratio statistic for probit and logit models.
Lemonte Artur José, Vanegas Luis Hernando   +1 more
doaj  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Una comparación entre la inferencia basada en las estadísticas de Wald y razón de verosimilitud en los modelos logit y probit vía Monte Carlo

Revista Colombiana de Estadística, 2005
Presentamos un estudio que evalúa y compara el desempeño de puebas de hipótesis e intervalos de confianza basados en la estadística de Wald con los basados en la estadística de razón de verosimilitud para los modelos logit y probit.
ARTUR JOSÉ LEMONTE, LUIS HERNANDO VANEGAS   +1 more
doaj