Results 31 to 40 of about 13,618 (264)

The immediate ex vivo covering and filling characteristics of antibiotic-loaded resorbable calcium sulfate paste around intramedullary nails [PDF]

Journal of Bone and Joint Infection
Background: Antibiotic-laden polymethyl methacrylate (PMMA)-coated intramedullary nails (IMNs) are an effective treatment for osteomyelitis, but they pose multiple disadvantages. Antibiotic-loaded resorbable calcium sulfate (ARCS) paste is an alternative
A. A. Hamilton, A. A. Hamilton, J. Wongcharoenwatana, J. S. Hoellwarth, J. S. Hoellwarth, A. T. Fragomen, A. T. Fragomen, S. R. Rozbruch, S. R. Rozbruch, T. J. Reif, T. J. Reif   +10 more
doaj   +1 more source

Lower extremity osseointegration for amputees with diabetes mellitus and vascular disease

OTA International
. Objective:. The aim of this study was to describe outcomes of osseointegration in amputees with diabetes mellitus (DM) and/or peripheral vascular disease (PVD). Design:. This was a case series. Setting:.
Jason S. Hoellwarth, MD, LaYow C. Yu, BA, Tyler D. DeSena, BA, Jidapa Wongcharoenwatana, MD, Taylor J. Reif, MD, S. Robert Rozbruch, MD   +5 more
doaj   +1 more source

Clinical implementation of MRI for evaluation of titanium press-fit osseointegration implants

OTA International
. Objective:. This investigation of the safety of titanium transcutaneous osseointegrated nail (TiTON) implants in a magnetic resonance imaging (MRI) suite evaluated whether any adverse events occurred for patients (pain, heating sensation, implant ...
LaYow C. Yu, BA, Tyler D. DeSena, BA, Alissa J. Burge, MD, S. Robert Rozbruch, MD, Taylor J. Reif, MD, Jason S. Hoellwarth, MD   +5 more
doaj   +1 more source

Multiplier Method for Predicting the Sitting Height Growth at Maturity: A Database Analysis

Children, 2022
This study aims to develop multipliers for the spine and sitting height to predict sitting height at maturity. With the aid of longitudinal and cross-sectional clinical databases, we divided the total sitting height, cervical, thoracic, and lumbar ...
Julio J. Jauregui, Larysa P. Hlukha, Philip K. McClure, Dror Paley, Mordchai B. Shualy, Maya B. Goldberg, John E. Herzenberg   +6 more
doaj   +1 more source

Hypertrophic nonunion management with distraction osteogenesis: a scoping review of the literature

OTA International
. Introduction:. Traditionally, stiff hypertrophic nonunions have been managed with open preparation of the nonunion site, which is then secured with internal fixation. Alternative surgical options are available including distraction osteogenesis with an
Benjamin J. Rouse, MD, Gerard A. Sheridan, MD, Brian J. Page, MD, Austin T. Fragomen, MD, S. Robert Rozbruch, MD   +4 more
doaj   +1 more source

Limb lengthening over plate

Indian Journal of Orthopaedics, 2012
The limb lengthening over plate eliminates the associated risk of infection with limb lengthening over intramedullary nail. We present our experience of limb lengthening in 15 patients with a plate fixed on the proximal segment, followed by corticotomy and application of external fixator.15 patients (7 females, 8 males) were included in this ...
Kulkarni, Ruta, Singh, Nishant, Kulkarni, Govind S, Kulkarni, Milind, Kulkarni, Sunil, Kulkarni, Vidisha   +5 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen, Ya‐Ting Chang, Levinia Lim, Pai‐Yi Chiu, Jung‐Lung Hsu, SangYun Kim, Wataru Narita, Na Young Ryoo, Kyoko Suzuki, Nagaendran Kandiah, Sebastian Crutch, Ming‐Chyi Pai   +11 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source