Results 261 to 270 of about 3,248,997 (314)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The limitations of limitations

IEEE Intelligent Systems, 2003
The authors consider human-centered computing, and argue that human factors and applied cognitive psychologists have not just been selective in regarding certain human characteristics as limitations, but have also selected the wrong things and for the wrong reasons.
Flach, John M., Hoffman, Robert R.
openaire   +3 more sources

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