Results 91 to 100 of about 63,993 (274)

Liraglutide dictates macrophage phenotype in apolipoprotein E null mice during early atherosclerosis

Cardiovascular Diabetology, 2017
Background Macrophages play a pivotal role in atherosclerotic plaque development. Recent evidence has suggested the glucagon-like peptide-1 receptor (GLP-1R) agonist, liraglutide, can attenuate pro-inflammatory responses in macrophages.
Robyn Bruen, Sean Curley, Sarina Kajani, Daniel Crean, Marcella E. O’Reilly, Margaret B. Lucitt, Catherine G. Godson, Fiona C. McGillicuddy, Orina Belton   +8 more
doaj   +1 more source

Mean field approximation of two coupled populations of excitable units

, 2012
The analysis on stability and bifurcations in the macroscopic dynamics exhibited by the system of two coupled large populations comprised of $N$ stochastic excitable units each is performed by studying an approximate system, obtained by replacing each ...
A. Pikovsky, C. W. Gardiner, D. Golomb, E. M. Izhikevich, F. M. Atay, G. Buzsáki, Igor Franović, J. Hale, J. L. P. Velazquez, Kristina Todorović, L. Arnold, L. Glass, Nebojša Vasović, Nikola Burić, P. A. Tass, S. Wiggins, S. A. Campbell, Y. A. Kuznetsov   +17 more
core   +1 more source

Neural Circuits between Nodose Ganglion and Pulmonary Neuroendocrine Cells Regulate Lung Inflammatory Responses

Advanced Science, EarlyView.
TRPA1+αCGRP+ sensory neurons in the nodose ganglion detect external insults such as lipopolysaccharide (LPS) and interact directly with pulmonary neuroendocrine cells (PNECs), promoting their activation and proliferation. This neural‐epithelial interaction amplifies lung inflammation.
Jie Chen, Shitao Xie, Zhekai Lin, Caiqi Zhao, Rujia Tao, Yingying Ma, Xiaoyan Chen, Renlan Wu, Qingjian Han, Pengfei Sui, Sheng Wang, Hongbin Ji, Hai Song, Xiaoming Zhang, Yangang Sun, Yuanlin Song, Xiao Su   +16 more
wiley   +1 more source

Canard explosion in delayed equations with multiple timescales [PDF]

, 2014
We analyze canard explosions in delayed differential equations with a one-dimensional slow manifold. This study is applied to explore the dynamics of the van der Pol slow-fast system with delayed self-coupling.
Krupa, Maciej, Touboul, Jonathan D.
core  

Generalized Mechanism Model for Ecosystem Hysteresis

Advanced Science, EarlyView.
A simplified model examines ecosystem transitions into alternative states after disturbances by leveraging positive and negative feedbacks. It identifies critical tipping points and quantifies hysteresis. Tests conducted on lakes, grasslands, and pitcher‐plant leaves align closely with empirical data and enable the prediction of recovery trajectories ...
Yanbin Hao, Xin Wang, Jie Liu, Mingzi Wu, Jianqing Du, Kai Xue, Xiaoning Song, Xiaoyong Cui, Tong Zhao, Yanfen Wang   +9 more
wiley   +1 more source

Influence of through-flow on linear pattern formation properties in binary mixture convection

, 1996
We investigate how a horizontal plane Poiseuille shear flow changes linear convection properties in binary fluid layers heated from below. The full linear field equations are solved with a shooting method for realistic top and bottom boundary conditions.
A. Bers, A. C. Newell, A. E. Deane, A. La Porta, Ch. Jung, D. Bensimon, D. Gutkowicz-Krusin, D. Gutkowicz-Krusin, D. P. Chock, E. Kaplan, E. Knobloch, E. Knobloch, E. Moses, G. W. T. Lee, G. Zimmermann, G. Zimmermann, H. B. Squire, H. Gao, H. R. Brand, H. W. Müller, H. W. Müller, H. W. Müller, H. Yahata, H. Yahata, I. Progogine, J. K. Platten, J. K. Platten, J. K. Platten, K. Lerman, M. A. Dominguez-Lerma, M. Bestehorn, M. Bestehorn, M. C. Cross, M. C. Cross, M. C. Cross, M. C. Cross, M. Liu, M. Lücke, N. D. Stein, O. Lhost, O. Lhost, P. Büchel, P. Glandsdorff, P. Huerre, P. Huerre, P. Kolodner, P. Kolodner, P. Le Gal, R. J. Briggs, R. J. Deissler, R. P. Behringer, S. Chandrasekhar, S. J. Linz, St. Hollinger, T. Clune, V. Croquette, V. Croquette, V. Steinberg, W. Barten, W. Barten, W. Hort, W. Schöpf, W. Schöpf   +62 more
core   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

A load margin calculation method considering optimized reactive power support

International Journal of Electrical Power & Energy Systems
With the development of modern low-carbon power systems, emerging ubiquitous reactive power supply gets more attention in improving power transmission capability.
Yuejian Wu, Xiaoming Dong, Tianguang Lu, Shunxiang Yu, Chengfu Wang, Zhengshuo Li   +5 more
doaj   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Nonlinear dynamics of attractive magnetic bearings [PDF]

The nonlinear dynamics of a ferromagnetic shaft suspended by the force of attraction of 1, 2, or 4 independent electromagnets is presented. Each model includes a state variable feedback controller which has been designed using the pole placement method ...
Hebbale, K. V., Taylor, D. L.
core   +1 more source