Results 191 to 200 of about 63,374 (271)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Dynamotypes for Dummies: A Toolbox, Atlas, and Tutorial for Simulating a Comprehensive Range of Realistic Synthetic Seizures. [PDF]

eNeuro
Sheckler C, Kish K, Walker Z, Barkelew G, Crisp DN, Szuromi MP, Saggio ML, Stacey WC.   +7 more
europepmc   +1 more source

Microstructure–Mechanical Response Relationship in Discontinuous Fiber‐Reinforced SMC Composites: Damage Mechanisms

Polymer Composites, EarlyView.
Architecture of SMC composites. ABSTRACT The mechanical performance of sheet molding compounds (SMCs) is dependent on microstructural characteristics determined by material composition and processing conditions. The study investigates standard SMCs, advanced SMCs (A‐SMCs), and low‐density SMCs (LD‐SMCs) under quasi‐static and fatigue loading to ...
Mohammadali Shirinbayan
wiley   +1 more source

Organic Electrochemical Neurons: Nonlinear Tools for Complex Dynamics. [PDF]

ACS Appl Electron Mater
Rivera-Sierra G, Fenollosa R, Bisquert J.   +2 more
europepmc   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

Stabilising spatiotemporal dynamics of mussel-algae coupled map lattices model via proportional-differential control. [PDF]

J Math Biol
Zhu Y, Ma X, Wang J, Frascoli F, Zhang T.   +4 more
europepmc   +1 more source

A Novel Method for Generating a Fused Ventilation–Perfusion Map Using CT‐Derived Ventilation and FDG‐PET for Lung Functional Avoidance in Radiotherapy: A Feasibility Study

Precision Radiation Oncology, EarlyView.
This study retrospectively analyzed two types of respiratory phase CT and PET/CT images of 20 lung cancer patients. After DIR and functional grading, three lung function images were developed, and their correlations and differences were evaluated. Abstract Background Pulmonary ventilation–perfusion function plays a crucial role in both radiotherapy ...
Suyan Bi, Zhitao Dai, Xingru Sun, Wan Fatihah Binti Wan Sohaimi, Ahmad Lutfi Bin Yusoff   +4 more
wiley   +1 more source

Covariance of the intertropical discontinuity and African easterly jet in Sahelian wet and dry years

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Intertropical discontinuity and African easterly jet (AEJ) positions are strongly correlated, with a more pronounced linear relationship across wet years. Surface heat flux anomalies modify low‐level temperature and sensible heat flux gradients that shift the AEJ core south of the gradient maxima in both composites.
Marian Amoakowaah Osei, Cornelia Klein, Christopher M. Taylor, Douglas J. Parker, Michael Baidu   +4 more
wiley   +1 more source

Metastability in the mixing/demixing of two species with reciprocally concentration-dependent diffusivity. [PDF]

Front Netw Physiol
Neiman AB, Dong X, Lindner B.
europepmc   +1 more source

A new method to identify and explain sources of precipitation modification, illustrated for the western Netherlands

Quarterly Journal of the Royal Meteorological Society, EarlyView.
This study develops a method to identify the source areas of precipitation events, as illustrated for the western part of the Netherlands. Radar‐based precipitation data are traced back to their source areas and machine‐learning techniques are used to identify hypothesized causes: urban heat, surface roughness, and air pollution. We find that urban and
Jelmer van der Graaff, Gert‐Jan Steeneveld   +1 more
wiley   +1 more source