Results 201 to 210 of about 63,993 (274)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Bifurcation-based dynamics and internal resonance in micro ring resonators for MEMS applications. [PDF]

Nonlinear Dyn
Azizi S, Haddad Khodaparast H, Madinei H, Younis MI, Rezazadeh G.   +4 more
europepmc   +1 more source

Bilateral Transcranial Doppler Monitoring During Neonatal Cardiac Surgery; Guidance for Clinical and Scientific Use

Pediatric Anesthesia, EarlyView.
ABSTRACT Introduction Neonates undergoing cardiac surgery face a high risk of neurological injury and neurodevelopmental complications. Transcranial Doppler monitoring is used and validated in adults to measure cerebral blood flow and can provide valuable insights into cerebral perfusion in neonates.
B. V. Martherus, T. Alderliesten, E. M. R. Fonteyn, I. Ceelie, D. J. van Vriesland, J. Nijman, H. Talacua, R. A. J. Nievelstein, J. Dudink, M. J. N. L. Benders, W. F. F. A. Buhre, K. van Loon   +11 more
wiley   +1 more source

Observing hidden neuronal states in experiments. [PDF]

PLoS Comput Biol
Amakhin D, Chizhov A, Girier G, Desroches M, Sieber J, Rodrigues S.   +5 more
europepmc   +1 more source

Lymphatic topology reveals a novel intranodal lympho‐venous shunt

The Journal of Pathology, EarlyView.
Abstract Understanding the lymphatic network is crucial for immunological research. Currently, a complete map of lymphatic drainage in mice is lacking. We present a detailed lymphatic system flow dynamic of two mouse strains with swollen lymph nodes (LNs), using region‐specific tracer injection and high‐resolution micro‐CT imaging to characterize LN ...
Ariunbuyan Sukhbaatar, Mishra Radhika, Akira Nakamura, Mori Shiro, Tsuyoshi Sugiura, Tetsuya Kodama   +5 more
wiley   +1 more source

Surface optimization governs the local design of physical networks. [PDF]

Nature
Meng X, Piazza B, Both C, Barzel B, Barabási AL.   +4 more
europepmc   +1 more source

Electrospun Nanofibres for Load‐Bearing Composite Materials—A Review of Techniques, Mechanical Properties and Durability

Polymer Composites, EarlyView.
Electrospun nanofibre for load‐bearing composite materials. ABSTRACT Electrospun nanofibres are emerging nanomaterials prized for their scalability, high surface area to volume ratio and yield. Their effectiveness in improving the mechanical properties of fiber reinforced composites is widely reported. Nanofibres could activate multiscale toughness and
Usaid Ahmed Shakil, Petr Hájek
wiley   +1 more source

Research on the Stability Model in Discrete Dynamical Systems with the Lorenz Attractor and the Kropotov-Pakhomov Neural Network. [PDF]

Entropy (Basel)
Gospodinova EA.
europepmc   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

From genes to patterns: five key dynamical systems concepts to decode developmental regulatory mechanisms. [PDF]

Development
Kadiyala U, Sprinzak D, Monk NAM, Taylor SE, Verd B, Sonnen KF, Moon L, Roeder AHK, Perez-Carrasco R, Formosa-Jordan P.   +9 more
europepmc   +1 more source