Results 101 to 110 of about 938,444 (341)

Faecal leukocyte esterase activity is an alternative biomarker in inflammatory bowel disease [PDF]

, 2015
Background: Leukocyte cytosolic proteins (e.g., calprotectin) are emerging biomarkers for inflammatory bowel disease. Leukocyte aryl esterase activity has been commonly used for sensitive detection of leukocytes in human body fluids such as urine.
De Vos, Martine, Delanghe, Joris, Dumoulin, Els, Himpe, Jonas, Speeckaert, Marijn, Van Biervliet, Stephanie   +5 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Fludarabine as a cost-effective adjuvant to enhance engraftment of human normal and malignant hematopoiesis in immunodeficient mice [PDF]

, 2018
There is still an unmet need for xenotransplantation models that efficiently recapitulate normal and malignant human hematopoiesis. Indeed, there are a number of strategies to generate humanized mice and specific protocols, including techniques to ...
A Rambaldi, A Terenzi, AM Carroll, AM Carroll, BS Andersson, CR Giver, D Niederwieser, DA Frank, DE Mosier, E McCormack, F Aversa, IF Khouri, K Tajima, L Luznik, L Weiss, M Furukawa, NC Kirkiles-Smith, S Goyama   +17 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Particle decays and stability on the de Sitter universe

, 2009
We study particle decay in de Sitter space-time as given by first order perturbation theory in a Lagrangian interacting quantum field theory. We study in detail the adiabatic limit of the perturbative amplitude and compute the "phase space" coefficient ...
A.G. Riess, A.M. Polyakov, B.S. Kay, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, D. Boyanovsky, G.W. Gibbons, H. Araki, Henri Epstein, J. Bros, J. Bros, J. Bros, J. Bros, J. Bros, J. Bros, J. Bros, Jacques Bros, K. Skenderis, L.F. Abbott, L.J. Slater, M. Veltman, N.J. Vilenkin, N.N. Bogolubov, O. Nachtmann, O.I. Marichev, R. Brunetti, R. Jost, S. Hollands, S. Hollands, S. Hollands, S. Perlmutter, Ugo Moschella, W. De Sitter, W. De Sitter, W. Magnus   +35 more
core   +1 more source

Determination of Tramadol in human plasma by HPLC with fluorescence detection [PDF]

, 2016
Tramadol is a centrally acting analgesic, atypical opioid, and although it is generally considered as a medicinal drug with a low potential for dependence, there is growing evidence of tramadol abuse in some countries.
Abdul Jalil Ebrahim, Zainab, Baconi, Daniela Luiza, Balalau, Cristian, Stan, Miriana, Tuchila, Cristian   +4 more
core   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

High-Performance Liquid Chromatographic Ultraviolet Determination of Memantine Hydrochloride after In Vitro Transdermal Diffusion Studies

Journal of Chemistry, 2013
The purpose of the present work was to validate an accurate and precise high-performance liquid chromatography (HPLC) method involving ultraviolet detection for the quantitative analysis of memantine hydrochloride.
Sergio del Rio-Sancho, César E. Serna-Jiménez, M. Aracely Calatayud-Pascual, Cristina Balaguer-Fernández, Andrés Femenía-Font, Virginia Merino, Alicia López-Castellano   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source