Results 261 to 270 of about 938,444 (341)

Analytical Methods for Melatonin Quantification: Advances, Challenges, and Clinical Applications. [PDF]

Pharmaceuticals (Basel)
Butiulca M, Farczadi L, Veres M, Azamfirei L.   +3 more
europepmc   +1 more source

Reliability at the Lower Limits of HIV-1 RNA Quantification in Clinical Samples: A Comparison of RT-PCR versus bDNA Assays

, 2009
Ronald Lubelchek, Blake Max, Caroline J. Sandusky, Bala Hota, David E. Barker   +4 more
openalex   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Multimatrix Detection and Quantification of the Advanced Glycation End Products Precursor Fructoselysine via UHPLC-HRMS/MS. [PDF]

Metabolites
Fenizia S, Manfredi M, Antoniotti V, Tini S, Baima J, Prodam F, Barberis E.   +6 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Adhesion and Formation of Bacterial Biofilm on Polydioxanone (PDO) Thread Cannulas: An In Vitro Evaluation. [PDF]

J Cosmet Dermatol
de Oliveira Rabelo H, de Andrade Cunha L, Pereira HMD, da Silva Ryal EPF, Wada LGTT, Ferreira EB, Gimenes F, Tognim MCB.   +7 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A Novel Ultra-Performance Liquid Chromatography-Electrospray Ionisation-Tandem Mass Spectrometry Method for Quantification of Imeglimin in Human Plasma: Application to a Bioequivalence Study. [PDF]

Anal Sci Adv
Wadie M, Badr KA, Hosny AA, Logoyda L, Sebai OME, Rezk MR.   +5 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Assessment of the feed additives tocopherol extracts from vegetable oils (1b306(i)), tocopherol-rich extracts from vegetable oils (delta rich) (1b306(ii)) and alpha-tocopherol (1b307) for all animal species for the renewal of their authorisation (ADM International Sàrl, DSM Nutritional Products Ltd., Europe-Asia Import Export GmbH., Vitiva d.o.o., Kaesler Nutrition GmbH, Kemin Nutrisurance Europe SRL, LUCTA S.A., Vitae Caps S.A.U/Kensing). [PDF]

EFSA J
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Galobart J, Manini P, Valeri P, Vettori MV, Pizzo F.   +20 more
europepmc   +1 more source