Results 181 to 190 of about 9,478,616 (387)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Predicting substance use behaviors with machine learning using small sets of judgment and contextual variables. [PDF]

Npj Ment Health Res
Bari S, Vike NL, Kim BW, Block M, Stefanopoulos L, Katsaggelos AK, Breiter HC.   +6 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

TCMEval-PA: a question-answering benchmark dataset for the prescription audit of Traditional Chinese Medicine. [PDF]

Sci Data
Wang B, Lu Y, Wang Z, Ge P, Wang G, Yao K, Peng S, Zhu Y.   +7 more
europepmc   +1 more source

Religious Mysticism and the Psychology of Religion: on the Question of the Limits of Reduction. Part 2

, 2023
Марк Владимирович Шугуров, Sergey I. Mozzhilin   +1 more
openalex   +2 more sources

Convergence questions for limit periodic continued fractions

, 1981
W. J. Thron, H. Waadeland
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Diagnosis, management, and prevention of bronchiolitis in primary care: a survey of Italian family paediatricians. [PDF]

Ital J Pediatr
Picca M, Pezzini C, Baggi E, Manzoni P, Mezzopane A, La Vecchia A, Milani GP.   +6 more
europepmc   +1 more source

Citizenship Revocation and the Question of Proportionate Consequences: Latest Judgement from the Danish Supreme Court Sheds New Light on the Limits of Article 8 of the European Convention on Human Rights

, 2023
Christian Brown Prener
openalex   +1 more source