Results 181 to 190 of about 10,153,724 (337)

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Applications of machine learning in drug discovery and development

Nature reviews. Drug discovery, 2019
J. Vamathevan, Dominic Clark, P. Czodrowski, I. Dunham, Edgardo Ferran, George Lee, Bin Li, A. Madabhushi, Parantu K. Shah, M. Spitzer, Shanrong Zhao   +10 more
semanticscholar   +1 more source

Improving social needs screening in general paediatrics through project SEEK. [PDF]

BMJ Open Qual
Feeney C, Monroe B, Agbim C, Kamath S, Parente V.   +4 more
europepmc   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

A Qualitative Analysis of Underexplored Barriers to Physicians Seeking Mental Health Care in Medical License Applications. [PDF]

J Grad Med Educ
Barrett E, Hicks K, Hunt L, Saddawi-Konefka D.   +3 more
europepmc   +1 more source

Real‐World Investigation of Satralizumab in Patients With Neuromyelitis Optica Spectrum Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Satralizumab, a monoclonal antibody targeting the interleukin‐6 receptor, has demonstrated efficacy in clinical trials for neuromyelitis optica spectrum disorder (NMOSD). However, its real‐world effectiveness and safety compared to conventional immunosuppressive therapies remain uncertain.
Li‐Tsung Lin, Hui‐An Lin, Sheng‐Feng Lin   +2 more
wiley   +1 more source

The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.

Cell Metabolism, 2014
S. Solon-Biet, A. Mcmahon, J. Ballard, K. Ruohonen, Lindsay E. Wu, V. Cogger, A. Warren, Xin Huang, N. Pichaud, Richard G Melvin, R. Gokarn, Mamdouh Khalil, N. Turner, G. Cooney, D. Sinclair, D. Raubenheimer, D. L. Le Couteur, S. Simpson   +17 more
semanticscholar   +1 more source

Perceptions from a Single Virtual Near-Peer Mock SBA Examination: A Retrospective Pre-Post Study Among Undergraduate Medical Students. [PDF]

Adv Med Educ Pract
Dalavaye N, Baskaran R, Ng VWS, Vyas R, Leveridge B, Hodgson M, Mukhopadhyay S, Peramuna Gamage M, Somani BK, Hassoulas A.   +9 more
europepmc   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Addressing social media platforms' influence on academic research. [PDF]

Humanit Soc Sci Commun
Heiss R, Freiling I.
europepmc   +1 more source