Results 231 to 240 of about 4,868,976 (301)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Weight-Management Services for Patients With Advanced Chronic Kidney Disease in Canada: A Survey of Nephrologists. [PDF]

Can J Kidney Health Dis
Chechulina V, Clemens KK, Vinson AJ, Chiu M, Young A, Moist L, OK TRANSPLANT Investigators.   +6 more
europepmc   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Reconsidering Outcome Structure and Transportability in the J-GESS Unified Risk Model for Upper Gastrointestinal Cancer. [PDF]

J Gastroenterol Hepatol
Hassan Z, Khan A, Farrukh V, Godugu S, Khokhar ME, Kumari K.   +5 more
europepmc   +1 more source

Large language models' performance in answering common patient questions about colonoscopy: an expert-based evaluation. [PDF]

BMC Gastroenterol
Güneş Aydemi̇r N, Yapar D, Demi̇r Avcı Y, Sonuvar ET, Aydemir AM.   +4 more
europepmc   +1 more source

Evaluating the First CE-Marked LLM-Based Chatbot for Evidence-Based Neurology. [PDF]

Eur J Neurol
Kirschner P, Epping PZ, Meuth SG, Pawlitzki M, Masanneck L.   +4 more
europepmc   +1 more source

Supporting patient understanding of cervical and ovarian cancer: how well does AI perform? [PDF]

Proc (Bayl Univ Med Cent)
Shin R, Shin A, Ramirez M, Bondre IL, Aviles DJ, Nugent EK.   +5 more
europepmc   +1 more source