Results 191 to 200 of about 5,581,980 (389)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Genetic evidence for GLP1R agonists in non-ischaemic heart failure. [PDF]

ESC Heart Fail
Le NN, Gill D, Padmanabhan S.
europepmc   +1 more source

Mapping opioid exposure through prescription data and postmortem analysis of opioid drugs in multiple tissues

British Journal of Clinical Pharmacology, EarlyView.
Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins, Alan Wells, Nimish Patel, Nicole Muttera, Mattia Trunfio, Alessandra Manca, Amedeo De Nicolò, Micol Ferrara, Stefano Bonora, Jessica Cusato, Alice Palermiti, Antonio D'Avolio, Marissa Borochoff, Patricia K. Riggs, Elizabeth Hastie, Rabia S. Atayee, Stephanie Solso, Cheryl Dullano, Vanessa Gomez‐Moreno, Tara Tenenbaum, Robert Deiss, Davey M. Smith, Antoine Chaillon, Sara Gianella   +23 more
wiley   +1 more source

Shadow AI in Consumer Health: The Case for Safe Adoption of National Health AI Assistants. [PDF]

Mayo Clin Proc Digit Health
Chua DY, McMahon BM, Kos S.
europepmc   +1 more source

The Non-Neutrality of Debt in Investment Timing: A New NPV Rule [PDF]

Limited liability debt financing of irreversible investments can affect investment timing through an entrepreneur's option value, even after compensating a lender for expected default losses.
Tarun Sabarwal
core  

Good News in a Bad Economy: Service Acquiesces on Pro-Taxpayer Application of Passive Activity Loss Rules to Limited Liability Companies

, 2012
Orly Mazur
openalex   +1 more source

Don't Buy Shares without It: Limited Liability Comes to American Express ℵ [PDF]

, 2006
Mark Weinstein, Andrew Ang, Joseph Chen, Wayne E. Ferson, Peter Z. Grossman   +4 more
openalex  

Practice, knowledge and attitude of physicians and pharmacists towards the spontaneous reporting system of adverse drug reactions in Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Introduction Introduction Reporting adverse drug reactions (ADRs) is essential for detecting drug risks. Despite legal obligations in Switzerland, underreporting remains an issue. This study assessed practice, knowledge and attitudes towards the spontaneous ADR reporting system among physicians and pharmacists.
Fiona A. Strobel, Thomas Stammschulte, Patrick E. Beeler   +2 more
wiley   +1 more source

Testing the performance of polygenic scores for multiple traits to explain cerebral palsy in two independent cohorts. [PDF]

EBioMedicine
Thomas JT, Berry ASF, Oetjens MT, Berry JG, MacLennan AH, Gordon SD, Hale AT, Olsen CM, Whiteman DC, Torene RI, Ledbetter DH, Martin NG, van Eyk CL, Gecz J, Myers SM, Mitchell BL, Corbett MA.   +16 more
europepmc   +1 more source

On the Choice Between Property Rules and Liability Rules [PDF]

When parties can bargain with each other in an externality situation, it is frequently argued that liability rules are preferable to property rules. The case for liability rules is thought to be strongest when the parties behave strategically, when the ...
A. Mitchell Polinsky
core