Results 51 to 60 of about 99,860 (313)

Methodological Approaches to Validation of Therapeutic Recombinant Proteins Production Based on the Quality by Design Concept

Биопрепараты: Профилактика, диагностика, лечение, 2018
Validation of production processes based on the Quality by Design (QbD) principles calls for thorough scientific understanding of the processes and enhancement of their stability by implementation of new technologies.
N. V. Stratonova, A. S. Lisov, A. N. Morozov, D. V. Tyupa, R. A. Khamitov   +4 more
doaj   +1 more source

Boron Nitride Reinforced Supramolecular Gels Nano‐Assembled with Fungicides toward Soil‐Borne Fungal Disease Management

Advanced Science, EarlyView.
This work demonstrates of 2D material‐mediated stimuli‐responsive transport in soft matter systems, pioneers a new class of nano‐bridged carriers with mechanically strengthening and programmable permeability characteristics designed to overcome persistent barriers in soil‐borne disease management.
Li Hao, Jialin Zeng, Weixian Qiu, Jinhui Wang, Xiaoshan Huang, Jiachun Wu, Zhensong Weng, Ziting Yin, Hongjun Zhou, Xinhua Zhou   +9 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Application of new generation phytobiotic adiCoxSOL® PF for coccidiosis prophylactics in poultry broilers

Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки, 2018
The new WHO recommendations aim to help preserve the effectiveness of antibiotics that are important for human medicine by reducing their unnecessary use in animals.
E. Cichocka, W. Drymel, P. Abramovych-Pindor, A. Didukh   +3 more
doaj   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Personal and joint liability of partner in limited liability company in UAE federal corporate law No. 32 of 2021. [PDF]

Heliyon, 2022
Kisswani N, Farah A.
europepmc   +1 more source

Redox‐Active NiOx‐Catalyzed Li+ Capture‐Extraction Strategy for tBP‐Free Spiro‐OMeTAD Enables Exceptional Damp‐Heat Stability in Perovskite Solar Cells

Advanced Science, EarlyView.
The redox‐active nature of NiOx enables ultrafast oxidative doping of spiro‐OMeTAD within seconds. Concurrently, NiOx‐Li+ coordination complexes formed during this redox process are selectively removed by filtration, effectively extracting residual Li+ ions from the film.
Yun Seop Shin, Minjin Kim, Jaehwi Lee, Chang Hyeon Yoon, Jongdeuk Seo, Gyeong‐Cheon Choi, Sujung Park, Min Jung Sung, Kyungnan Son, Sungjun Hong, Inyoung Jeong, Junseop Byeon, Yimhyun Jo, Dongmin Lee, Minseong Kim, Shinuk Cho, Ji‐Youn Seo, Jin Young Kim, Dong Suk Kim, SeJin Ahn   +19 more
wiley   +1 more source

Integrated anthropo-technogenic pressures on urban territories of some of large industrial cities and federal resorts of Russian Federation

Известия высших учебных заведений: Геология и разведка, 2016
The assessment of the total impact of environmental factors on the health of the population in 30 cities of Russia is estimated. The evaluation was performed on the largest integrated anthropotechnogenic impact on the environment.
I. S. Pomelyayko, V. I. Pomelyayko
doaj   +2 more sources

Study on lightning risk assessment and early warning for UHV DC transmission channel

High Voltage, 2019
Operation data show lightning faults account for >70% for the main ultra-high voltage (UHV) DC transmission channels, very different from the design view.
Shanqiang Gu, Jian Wang, Jian Wang, Min Wu, Juntian Guo, Chun Zhao, Jian Li   +6 more
doaj   +1 more source