Results 201 to 210 of about 195,901 (353)

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

open access: yesChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel   +5 more
wiley   +1 more source

Finding the balance between academic productivity and impact: evaluation of the Botswana - University of Pennsylvania partnership over a 5-year timeframe. [PDF]

open access: yesBMJ Glob Health
Cancedda C   +15 more
europepmc   +1 more source

Online Accessibility of Local Public Enterprise Financial Statements in Indonesia: Can it be Predicted by Institutional Traits of Parent Local Governments?

open access: yesPublic Administration and Development, EarlyView.
ABSTRACT This study aims to fill the research gap within the principal‐agent framework by investigating the effect of local government (LG) institutional characteristics on the online accessibility of local public enterprises' (LPEs) financial statements.
Ray Ferza, Don S. Lee
wiley   +1 more source

Policy Capacity for Novel Technology Adoption: Developmental Insights From Singapore's AI Adoption in Long‐Term Care

open access: yesPublic Administration and Development, EarlyView.
ABSTRACT Worldwide, artificial intelligence‐driven technologies, including robotics and autonomous systems (RAS), are adopted to address manpower shortages in long‐term care. However, their effective use requires a reasonable degree of policy capacity across individual‐, organisational‐ and system‐levels.
Si Ying Tan, Lili Li, Araz Taeihagh
wiley   +1 more source

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