Results 51 to 60 of about 5,502,647 (347)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

HSP70 and HSP90 in Cancer: Cytosolic, Endoplasmic Reticulum and Mitochondrial Chaperones of Tumorigenesis

Frontiers in Oncology, 2022
HSP70 and HSP90 are two powerful chaperone machineries involved in survival and proliferation of tumor cells. Residing in various cellular compartments, HSP70 and HSP90 perform specific functions.
Zarema Albakova, Zarema Albakova, Yana Mangasarova, Akhmet Albakov, Liliya Gorenkova   +4 more
doaj   +1 more source

In Search of a Regime of Limited Liability in Malaysian Partnerships [PDF]

, 2002
For many years, partnership has been the oldest and the most basic entity choice which combines the efforts of more than one individual. As commerce progresses, partnership has to compete with other business entities, especially the company which gains ...
Abd Ghadas, Zuhairah Ariff
core  

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

HSP90 multi-functionality in cancer

Frontiers in Immunology
The 90-kDa heat shock proteins (HSP90s) are molecular chaperones essential for folding, unfolding, degradation and activity of a wide range of client proteins. HSP90s and their cognate co-chaperones are subject to various post-translational modifications,
Zarema Albakova, Zarema Albakova
doaj   +1 more source

The use of information systems for logistics and supply chain management in South East Europe: Current status and future direction [PDF]

, 2008
This research aims to investigate the current status and future direction of the use of information systems for logistics and supply chain management (LSCM) in South East Europe.
Dimitriadis, N., Gunasekaran, A., Kehajova, M., Ketikidis, K.H., Koh, S.C.L.   +4 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Epidemiological investigation of poultry infectious in Kazakhstan (2021–2024)

Frontiers in Veterinary Science
IntroductionThis study examines the epidemiological dynamics and genetic diversity of major avian infectious diseases in Kazakhstan, including highly pathogenic avian influenza (HPAI), Newcastle disease virus (NDV), and others.
Karlygash B. Zikibayeva, Asset A. Svanbayev, Nurlan N. Akhmetsadykov, Kamshat N. Kudaibergenova, Shynar N. Akhmetsadykova, Ernur N. Nurolda, Aidyn I. Kydyrmanov   +6 more
doaj   +1 more source

Promoting Active and Sustained School-Business Partnerships: An Exploratory Case Study of an IT Academy

, 2017
In support of the national push for promoting career readiness, school-business partnerships have been noted as an important support strategy. However, there is limited research in the context of career academies. Thus, we sought to explore the nature of
Brookins, Simone J., Fletcher, Edward C, Jr., Hernandez-Gantes, Victor M.   +2 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source