Results 151 to 160 of about 4,089,631 (323)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
, 2006 L'exemple le plus illustratif des limites de la gouvernance des risques au sein de l'espace de la branche est celui de la formation professionnelle continue, c'est pourquoi nous proposons de revenir brièvement, dans un premier temps, sur quelques uns des
Verdier, Eric
core +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
M@GM@, 2010 Estableciendo una relación estrecha entre espacio, tiempo e imaginario, este escrito intenta tratar la gran separación Norte- Sur, acaecida con la hipermodernidad y sus consecuencias sobre la destrucción del espacio del Sur ; la cuestión de fondo encara ...
Mabel Franzone
doaj
, 2013 V doktorski disertaciji se obravnava vprašanje ali iz konvergence grafov navzgor polzveznih veznih funkcij sledi konvergenca ustreznih pripadajočih inverznih limit za konstantna inverzna zaporedja kompaktnih metričnih prostorov. V uvodnem delu se vpeljejo osnovni pojmi kot so navzgor polzvezne funkcije, inverzna zaporedja in inverzne limite.
openaire +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Arthur Danto e a representação como limite da arte
Artefilosofia, 2017 A experiência, tão marcante para Danto, de encontrar uma pilha de caixas idênticas às caixas de esponja de aço Brillo expostas em uma galeria o conduz a uma teoria assentada na ideia de que qualquer coisa pode, em princípio, ser uma obra de arte.
Debora Pazetto Ferreira
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source