Results 111 to 120 of about 64,070 (252)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Compliance of feed limits, does not mean compliance of food limits [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2009
The carry-over of contaminants from feed to animal food products is an important aspect of the animal production chain. For a proper containment, limits for feed as well food products are fixed for a series of chemicals, e.g. dioxins and dioxin-like PCBs,
van Raamsdonk LWD., van Eijkeren JCH., Meijer GAL., Rennen M., Zeilmaker MJ., Hoogenboom L.A.P., Mengelers M.   +6 more
doaj  

Considering pedagogical content knowledge in the context of research on teaching: An example from technology.

, 2003
When thinking about teaching, the pedagogical content knowledge of teachers cannot be ignored. We argue that pedagogical content knowledge is a major determiner of teaching practice and is central to teachers' curriculum decision-making at the classroom ...
Jones, Alister, Moreland, Judy
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Epistemic and ethical limits of large language models in evidence-based medicine: from knowledge to judgment

Frontiers in Digital Health
BackgroundThe rapid evolution of general large language models (LLMs) provides a promising framework for integrating artificial intelligence into medical practice.
Wenxiu Qi, Longfei Pan
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

McDowell, Gettier, and the bipartite account of perceptual knowledge

, 2008
In his essay, “Knowledge and the Internal Revisited”, John McDowell claims that “seeing that p constitutes false-hood excluding justification for believing that p.” In this thesis I attempt to construct an account of perceptual knowledge that exploits ...
Archer, Adrian Avery
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

“Limits” at the human–nature interface: a meta-ethnographic review

Ecology and Society
Sustainability issues are increasingly viewed through the lens of environmental and sociopolitical limits. However, so far there is no conceptual cartography of limit-related statements in the scientific literature dealing with nature–society relations ...
Sandrine Allain, Lucas Berard-Chenu, Thomas Bolognesi, Isabelle Boulangeat, Arnaud Buchs, Jonathan Cognard, Matthieu Combaud, Grace Kassis, Jean-François Ruault, Yves Schaeffer   +9 more
doaj   +1 more source