Results 211 to 220 of about 167,013,277 (277)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Relative and absolute reliability of medial knee joint space width measurement using ultrasound imaging during valgus stress testing. [PDF]

PLoS One
Hayashi R, Kawaji H, Kojima S.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Measuring physical activity over the life course: cross-cultural validation and measurement properties of the lifetime total physical activity questionnaire for Brazilian older adults. [PDF]

Eur Rev Aging Phys Act
Batista de Souza N, Guimarães Paiva L, Friedenreich C, Medina Dutra de Oliveira T, Carneiro Oliveira C, José A, Malaguti C.   +6 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Factors Influencing Self-Reported Health in Puerto Rican Populations: A Systematic Review. [PDF]

Health Sci Rep
Razzano AV.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Salivary and serum levels of NT-proBNP, troponin, and high-sensitivity C-reactive protein in patients with heart failure. [PDF]

PLoS One
Melo Viegas RF, Cortelli SC, Romeiro Aquino D, Costa FO, Hentges B, Pádua de Magalhães VC, Silva RAF, Fernandes Ruivo G, Cortelli JR.   +8 more
europepmc   +1 more source

Aflatoxin exposure and health impacts: global burden and advances in detection technologies. [PDF]

Genes Environ
Bereda G.
europepmc   +1 more source

Serial Bogota bag tightening: A pragmatic advance in open abdomen management for resource-limited settings. [PDF]

World J Gastrointest Pharmacol Ther
Feyissa GD.
europepmc   +1 more source