Results 301 to 310 of about 4,881,979 (331)

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition. [PDF]

Elife
Kavaklioglu G, Podhornik A, Vcelkova T, Marjanovic J, Beck MA, Phan-Canh T, Mair T, Miccolo C, Drino A, Doni M, Egger G, Chiocca S, Modic M, Seiser C.   +13 more
europepmc   +1 more source

LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker. [PDF]

NPJ Precis Oncol
de Santiago PR, Sato S, Zhang SJ, Dougher MC, Devins KM, Bilecz AJ, Rayamajhi S, Mingo G, Rendulich HS, Feng Y, Wu C, Taylor MS, Zhuravlev Y, Jung E, Omran DK, Wang TL, Shih IM, Schwartz LE, Kim S, Morgan MA, Tanyi JL, Burns KH, Lengyel E, Parra-Herran C, Godwin AK, Walt DR, Drapkin R.   +26 more
europepmc   +1 more source

Altered Methylation Levels in LINE-1 in Dental Pulp Stem Cell-Derived Osteoblasts. [PDF]

Int Dent J
Prucksakorn T, Mutirangura A, Pavasant P, Subbalekha K.   +3 more
europepmc   +1 more source

DNA Methylation of iNOS, eNOS, TP53 and LINE-1 in Gingival Tissues of Cigarette Smokers, Heat-Not-Burn Smokers and Never Smokers: An Exploratory Study. [PDF]

Clin Exp Dent Res
Rasperini G, Codari M, Moiana A, Tarantini L, Bollati V, Bellucci G, Consonni D, Larsson L, Asa'ad F.   +8 more
europepmc   +1 more source

LINE-1-Induced Retrotransposition Affects Early Preimplantation Embryo DNA Integrity and Pluripotency. [PDF]

Int J Mol Sci
Sakaloglou P, Lazaros L, Bouba I, Markoula S, Zikopoulos A, Drakaki E, Anagnostaki I, Potiris A, Stavros S, Gerede A, Domali E, Drakakis P, Tzavaras T, Georgiou I.   +13 more
europepmc   +1 more source

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Adami A, Garza R, Gerdes P, Johansson PA, Dorazehi F, Koutounidou S, Castilla-Vallmanya L, Atacho DA, Sharma Y, Johansson JG, Tam O, Kirkeby A, Barker RA, Gale-Hammell M, Douse CH, Jakobsson J.   +15 more
europepmc   +1 more source

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LINE-1: a human transposable element

Gene, 1993
Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells of epithelial origin.
M F, Singer, V, Krek, J P, McMillan, G D, Swergold, R E, Thayer   +4 more
openaire   +2 more sources

Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1 -encoded protein

Gene, 1993
Nucleotide sequences near the 5' ends of some long interspersed elements-1 (LINE-1) from Homo sapiens (L1Hs) are undermethylated in cell lines which produce a L1Hs-encoded protein. In contrast, these sequences are methylated in cell lines with little or no detectable L1Hs expression.
R E, Thayer, M F, Singer, T G, Fanning
openaire   +2 more sources

Targeted cloning of a subfamily of LINE-1 elements by subfamily-specific LINE-1-PCR

Mammalian Genome, 1993
Subfamily-specific LINE-1 PCR (SSL1-PCR) is the targeted amplification and cloning of defined subfamilies of LINE-1 elements and their flanking sequences. The targeting is accomplished by incorporating a subfamily-specific sequence difference at the 3' end of a LINE-1 PCR primer and pairing it with a primer to an anchor ligated within the flanking ...
N C, Casavant, S C, Hardies
openaire   +2 more sources

LINE-1 Retrotransposition in the Nervous System

Annual Review of Cell and Developmental Biology, 2012
Long interspersed element-1 (LINE-1 or L1) is a repetitive DNA retrotransposon capable of duplication by a copy-and-paste genetic mechanism. Scattered throughout mammalian genomes, L1 is typically quiescent in most somatic cell types. In developing neurons, however, L1 can express and retrotranspose at high frequency.
Charles A, Thomas, Apuã C M, Paquola, Alysson R, Muotri   +2 more
openaire   +2 more sources