Results 301 to 310 of about 4,813,932 (329)

Altered Methylation Levels in LINE-1 in Dental Pulp Stem Cell-Derived Osteoblasts. [PDF]

Int Dent J
Prucksakorn T, Mutirangura A, Pavasant P, Subbalekha K.   +3 more
europepmc   +1 more source

LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis. [PDF]

Heliyon
Bagheri A, Jafari-Koshki T, Alizadeh L, Raeisi M, Moaddab Y, Karimi A.   +5 more
europepmc   +1 more source

LINE-1-Induced Retrotransposition Affects Early Preimplantation Embryo DNA Integrity and Pluripotency. [PDF]

Int J Mol Sci
Sakaloglou P, Lazaros L, Bouba I, Markoula S, Zikopoulos A, Drakaki E, Anagnostaki I, Potiris A, Stavros S, Gerede A, Domali E, Drakakis P, Tzavaras T, Georgiou I.   +13 more
europepmc   +1 more source

LINE-1 retrotransposons regulate the exit of human pluripotency and early brain development

Adami A, Garza R, Gerdes P, Johansson PA, Dorazehi F, Koutounidou S, Castilla-Vallmanya L, Atacho DA, Sharma Y, Johansson JG, Tam O, Kirkeby A, Barker RA, Gale-Hammell M, Douse CH, Jakobsson J.   +15 more
europepmc   +1 more source

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LINE-1: a human transposable element

Gene, 1993
Among the 10(5) LINE-1 sequences (L1Hs) in the human genome are one or more 6-kb segments that are active retrotransposons. Expression of these retrotransposons appears to be favored in cells of germ line origin, as well as in some other tumor cells of epithelial origin.
M F, Singer, V, Krek, J P, McMillan, G D, Swergold, R E, Thayer   +4 more
openaire   +2 more sources

Undermethylation of specific LINE-1 sequences in human cells producing a LINE-1 -encoded protein

Gene, 1993
Nucleotide sequences near the 5' ends of some long interspersed elements-1 (LINE-1) from Homo sapiens (L1Hs) are undermethylated in cell lines which produce a L1Hs-encoded protein. In contrast, these sequences are methylated in cell lines with little or no detectable L1Hs expression.
R E, Thayer, M F, Singer, T G, Fanning
openaire   +2 more sources

Targeted cloning of a subfamily of LINE-1 elements by subfamily-specific LINE-1-PCR

Mammalian Genome, 1993
Subfamily-specific LINE-1 PCR (SSL1-PCR) is the targeted amplification and cloning of defined subfamilies of LINE-1 elements and their flanking sequences. The targeting is accomplished by incorporating a subfamily-specific sequence difference at the 3' end of a LINE-1 PCR primer and pairing it with a primer to an anchor ligated within the flanking ...
N C, Casavant, S C, Hardies
openaire   +2 more sources

LINE-1 Retrotransposition in the Nervous System

Annual Review of Cell and Developmental Biology, 2012
Long interspersed element-1 (LINE-1 or L1) is a repetitive DNA retrotransposon capable of duplication by a copy-and-paste genetic mechanism. Scattered throughout mammalian genomes, L1 is typically quiescent in most somatic cell types. In developing neurons, however, L1 can express and retrotranspose at high frequency.
Charles A, Thomas, Apuã C M, Paquola, Alysson R, Muotri   +2 more
openaire   +2 more sources

การเปลี่ยนแปลงของระดับเมธิลเลชั่นของ LINE-1 ในมะเร็งระหว่างที่มีการแพร่กระจาย

ที่มาและปัญหา: มะเร็งหลายชนิดนั้นมักพบการลดลงของระดับเมธิลเลชั่นของลำดับซ้ำ LINE-1 เมื่อเปรียบเทียบกับในเซลล์ปกติโดยเฉพาะในมะเร็งที่มีการพัฒนาอย่างเป็นลำดับขั้น จึงมีความน่าสนใจว่าการเกิดการลดลงของระดั บเมธิลเลชั่นของ LINE-1 นั้นอาจจะมีความเกี่ยวข้องกับกลไกการแพร่กระจายของมะเร็งที่มีการพัฒนาของเซลล์มะเร็งอย่างเป็นลำดับขั้น วัตถุประสงค์:เปรียบเทียบระด ...
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Adar1 restricts line-1 retrotransposition

2017
Adenosine deaminases acting on RNA (ADARs) are enzymes that catalyze the hydrolytic deamination of Adenosine (A) to Inosine (I) (AàI) in double-stranded RNA (dsRNA) substrates. This process is called RNA editing. In literature there are many studies describing ADAR1 as regulator of the replication of different viruses, exerting either a proviral or ...
openaire   +2 more sources