Results 151 to 160 of about 8,892,596 (302)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
On the Energy Efficiency of Mixed-Line-Rate Networks
, 2010 We present a mathematical model to evaluate the energy efficiency of mixed-line-rate (MLR) optical networks.
S. Sarkar +3 more
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source
The impact of competition on productive efficiency in European railways [PDF]
This paper empirically explores the relationship between competition design and productive efficiency in the railway industry. We use Data Envelopment Analysis (DEA) to construct efficiency scores, and explain these scores, using variables reflecting ...
Machiel Mulder +2 more
core
Energy efficiency and the rebound effect [PDF]
, 2009 In recent years the argument that rebound effects, triggered by economy-wide price and income effects, may partially or wholly offset reductions in energy consumption expected from energy efficiency improvements has gained a great deal of attention in ...
Turner, Karen
core
Molecular Oncology, EarlyView.Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both +7 more
wiley +1 more source
Efficiency analysis of automatic production line
This thesis focuses on analyzing the efficiency of a yogurt production line. The goal is to describe a real production line and based on this description, create a digital model in Tecnomatix Plant Simulation, which will be used to analyze efficiency and
Bortlík, Dominik
core
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Achieving Profit and Efficiency with On-Line Optimization
Measurement + Control, 1996 Doug Scott
doaj +1 more source