Results 241 to 250 of about 8,892,596 (302)

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Impact of water deprivation on broilers divergently selected for water efficiency. [PDF]

Front Physiol
Whittle RH, Fraley GS, Scanes CG, Orlowski-Workman SK, Maqueda MA, Nelson AH, Grider Z, Weimer SL.   +7 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

CRISPR/Cas9-based repair of a heterozygous HNF1A mutation in patient-derived hiPSCs. [PDF]

Hum Genet
Skoczek D, Hohendorff J, Malecki MT, Roig-Merino A, Bak RO, Kachamakova-Trojanowska N.   +5 more
europepmc   +1 more source

Establishment of a scalable engineered cell-line platform for direct, GMP-grade production of eVLP vectors enabling streamlined generation of gene-edited CAR-T/NK cells. [PDF]

Front Immunol
Lin W, Shi J, Chen H, Chai R, Zhu S, Chen L, Mo S, Wang Z, Li H, Feng Y, Zhao L, Chen J, Yu G, Lu T, Wang J.   +14 more
europepmc   +1 more source

Exergy-guided multiphysics analysis of transport irreversibilities in PEMFC flow-field architectures. [PDF]

Front Chem
Alrwashdeh S.
europepmc   +1 more source

Evaluation of 7 Tesla pTx Body Coils Regarding Transmit and Receive Performance. [PDF]

Magn Reson Med
Grimm JA, Kraff O, May MW, Lutz M, Orzada S, Fiedler TM, Moeller S, Schmidt S, Quick HH, Nagel AM, Ladd ME, Schmitter S.   +11 more
europepmc   +1 more source