Results 91 to 100 of about 4,649,293 (309)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Cogent EngineeringA graph’s b-coloring admits proper coloring and has the extra characteristic of having a dominating node in each color-class in the graph. [Formula: see text] the b-chromatic number, is the largest integer k for which G can be colored with k colors using
Foram Chandarana +5 more
doaj +1 more source
Line and Subdivision Graphs Determined by
Mathematics, 2019 Let T 4 = { ± 1 , ± i } be the subgroup of fourth roots of unity inside T , the multiplicative group of complex units. For a T 4 -gain graph Φ = ( Γ , T 4 , φ ) , we introduce gain functions on ...
Abdullah Alazemi +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Rooted Complete Minors in Line Graphs with a Kempe Coloring [PDF]
, 2019 Matthias Kriesell, Samuel Mohr
openalex +1 more source
On The Local Metric Dimension of Line Graph of Special Graph
, 2016 Let G be a simple, nontrivial, and connected graph. is a representation of an ordered set of k distinct vertices in a nontrivial connected graph G. The metric code of a vertex v , where , the ordered of k -vector is representations of v with respect to
M. Marsidi +3 more
semanticscholar +1 more source