Results 91 to 100 of about 1,947,729 (286)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Extension of Space Syntax Methods to Generic Urban Variables
Urban Science, 2018 We studied generalization of a method for extending configurational studies to variables that are not exclusively geographical, in order to allow investigation of generic relationships in the built environment.
Roberto D’Autilia, Marco Spada
doaj +1 more source
Hypergraph Learning with Line Expansion
, 2020 Previous hypergraph expansions are solely carried out on either vertex level or hyperedge level, thereby missing the symmetric nature of data co-occurrence, and resulting in information loss.
Abdelzaher, Tarek +3 more
core
Minimizing the Cost of Team Exploration
, 2019 A group of mobile agents is given a task to explore an edge-weighted graph $G$, i.e., every vertex of $G$ has to be visited by at least one agent. There is no centralized unit to coordinate their actions, but they can freely communicate with each other ...
BL Golden +13 more
core +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Glasgow Mathematical Journal, 1976 In this paper all graphs will be ordinary graphs, i.e. finite, undirected, and without loops or multiple edges. For points x and y of a graph G, we shall indicate that x is adjacent to y by writing x ⊥ y, and if x is not adjacent to y we shall write xy.
openaire +2 more sources
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
On two energy-like invariants of line graphs and related graph operations
Journal of Inequalities and Applications, 2016 For a simple graph G of order n, let μ 1 ≥ μ 2 ≥ ⋯ ≥ μ n = 0 $\mu_{1}\geq\mu_{2}\geq\cdots\geq\mu_{n}=0$ be its Laplacian eigenvalues, and let q 1 ≥ q 2 ≥ ⋯ ≥ q n ≥ 0 $q_{1}\geq q_{2}\geq\cdots\geq q_{n}\geq0$ be its signless Laplacian eigenvalues.
Xiaodan Chen, Yaoping Hou, Jingjian Li
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source