Results 101 to 110 of about 1,946,730 (334)
Extension of Space Syntax Methods to Generic Urban Variables
Urban Science, 2018 We studied generalization of a method for extending configurational studies to variables that are not exclusively geographical, in order to allow investigation of generic relationships in the built environment.
Roberto D’Autilia, Marco Spada
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Graphs with odd and even distances between non-cut vertices [PDF]
Opuscula MathematicaWe prove that in a connected graph, the distances between non-cut vertices are odd if and only if it is the line graph of a strong unique independence tree.
Kateryna Antoshyna, Sergiy Kozerenko
doaj +1 more source
Hypergraph Learning with Line Expansion
, 2020 Previous hypergraph expansions are solely carried out on either vertex level or hyperedge level, thereby missing the symmetric nature of data co-occurrence, and resulting in information loss.
Abdelzaher, Tarek +3 more
core
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
On two energy-like invariants of line graphs and related graph operations
Journal of Inequalities and Applications, 2016 For a simple graph G of order n, let μ 1 ≥ μ 2 ≥ ⋯ ≥ μ n = 0 $\mu_{1}\geq\mu_{2}\geq\cdots\geq\mu_{n}=0$ be its Laplacian eigenvalues, and let q 1 ≥ q 2 ≥ ⋯ ≥ q n ≥ 0 $q_{1}\geq q_{2}\geq\cdots\geq q_{n}\geq0$ be its signless Laplacian eigenvalues.
Xiaodan Chen, Yaoping Hou, Jingjian Li
doaj +1 more source
Towards on-line Ohba's conjecture [PDF]
, 2012 The on-line choice number of a graph is a variation of the choice number defined through a two person game. It is at least as large as the choice number for all graphs and is strictly larger for some graphs. In particular, there are graphs $G$ with $|V(G)
Kozik, Jakub, Micek, Piotr, Zhu, Xuding
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
ncRPI-LGAT: Prediction of ncRNA-protein interactions with line graph attention network framework. [PDF]
Comput Struct Biotechnol J, 2023 Han Y, Zhang SW.
europepmc +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source