Results 101 to 110 of about 4,649,293 (309)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Atom-bond sum-connectivity index of line graphs [PDF]

Discrete Mathematics Letters, 2023
Yanyan Ge, Zhen Lin, Jiajia Wang
doaj   +1 more source

A novel algebraic technique for adjacency matrices of some derived graphs

Mathematical and Computer Modelling of Dynamical Systems
Graph energy has been the main concern of spectral graph theory in the last five decades. The classical graph energy is the sum of the absolute values of the eigenvalues of the adjacency matrix. In many research papers, different versions of graph energy
Hacer Ozden Ayna, Aysun Yurttas Gunes, Sadik Delen, Medha Itagi Huilgol, Berke Ozmen, Ismail Naci Cangul   +5 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Combinatorial analysis of line graphs: domination, chromaticity, and Hamiltoniancity

AIMS Mathematics
Line graphs are a fundamental class of graphs extensively studied for their structural properties and applications in diverse fields such as network design, optimization, and algorithm development.
Yubin Zhong, Sakander Hayat, Suliman Khan, Vito Napolitano, Mohammed J. F. Alenazi   +4 more
doaj   +1 more source

On •-Line Signed Graphs L•(S)

Discussiones Mathematicae Graph Theory, 2015
A signed graph (or sigraph for short) is an ordered pair S = (Su,σ), where Su is a graph, G = (V,E), called the underlying graph of S and σ : E → {+,−} is a function from the edge set E of Su into the set {+,−}.
Sinha Deepa, Dhama Ayushi
doaj   +1 more source

Key role for inhibins in effective T cell activation, migration and Th17 differentiation

FEBS Open Bio, EarlyView.
Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco, Roxana Olguín‐Alor, Lizbeth Bolaños‐Castro, Alexandra Morales‐Cruz, Marisol De La Fuente‐Granada, Gloria Soldevila   +5 more
wiley   +1 more source

Efficient Direct Reconstruction of Bipartite (Multi)Graphs from Their Line Graphs Through a Characterization of Their Edges

Mathematics
We study the line graphs of bipartite multigraphs, which naturally arise in combinatorics, game theory, and applications such as scheduling and motion planning.
Drago Bokal, Janja Jerebic
doaj   +1 more source

Perfect Set of Euler Tours of Kp,p,p

Discussiones Mathematicae Graph Theory, 2016
Bermond conjectured that if G is Hamilton cycle decomposable, then L(G), the line graph of G, is Hamilton cycle decomposable. In this paper, we construct a perfect set of Euler tours for the complete tripartite graph Kp,p,p for any prime p and hence ...
Govindan T., Muthusamy A.
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source