Results 51 to 60 of about 4,649,293 (309)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

On two energy-like invariants of line graphs and related graph operations

open access: yesJournal of Inequalities and Applications, 2016
For a simple graph G of order n, let μ 1 ≥ μ 2 ≥ ⋯ ≥ μ n = 0 $\mu_{1}\geq\mu_{2}\geq\cdots\geq\mu_{n}=0$ be its Laplacian eigenvalues, and let q 1 ≥ q 2 ≥ ⋯ ≥ q n ≥ 0 $q_{1}\geq q_{2}\geq\cdots\geq q_{n}\geq0$ be its signless Laplacian eigenvalues.
Xiaodan Chen, Yaoping Hou, Jingjian Li
doaj   +1 more source

On a Combinatorial Approach to Studying the Steiner Diameter of a Graph and Its Line Graph

open access: yesMathematics, 2022
In 1989, Chartrand, Oellermann, Tian and Zou introduced the Steiner distance for graphs. This is a natural generalization of the classical graph distance concept. Let Γ be a connected graph of order at least 2, and S\V(Γ).
Hongfang Liu   +3 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

open access: yesMolecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani   +14 more
wiley   +1 more source

Line graphs of directed graphs I [PDF]

open access: yesTransactions on Combinatorics
We determine the forbidden induced subgraphs for the intersection of the classes of chordal bipartite graphs and line graphs of acyclic directed graphs. This is a first step towards finding the forbidden induced subgraphs for the class of line graphs of ...
Vaidyanathan Sivaraman, Daniel Slilaty
doaj   +1 more source

ConvGraph: Community Detection of Homogeneous Relationships in Weighted Graphs

open access: yesMathematics, 2021
This paper proposes a new method, ConvGraph, to detect communities in highly cohesive and isolated weighted graphs, where the sum of the weights is significantly higher inside than outside the communities.
Héctor Muñoz   +4 more
doaj   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

On the r-dynamic coloring of some fan graph families

open access: yesAnalele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2021
In this paper, we determine the r-dynamic chromatic number of the fan graph Fm,n and determine sharp bounds of this graph invariant for four related families of graphs: The middle graph M(Fm,n), the total graph T (Fm,n), the central graph C(Fm,n) and the
Falcón Raúl M.   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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