Results 61 to 70 of about 1,844,339 (310)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Reverse Line Graph Construction: The Matrix Relabeling Algorithm MARINLINGA Versus Roussopoulos's Algorithm [PDF]
, 2010 We propose a new algorithm MARINLINGA for reverse line graph computation, i.e., constructing the original graph from a given line graph. Based on the completely new and simpler principle of link relabeling and endnode recognition, MARINLINGA does not ...
Liu, D. +2 more
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Bar 1-Visibility Drawings of 1-Planar Graphs
, 2013 A bar 1-visibility drawing of a graph $G$ is a drawing of $G$ where each vertex is drawn as a horizontal line segment called a bar, each edge is drawn as a vertical line segment where the vertical line segment representing an edge must connect the ...
A.M. Dean +13 more
core +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
Maintenance of Strongly Connected Component in Shared-memory Graph
, 2018 In this paper, we present an on-line fully dynamic algorithm for maintaining strongly connected component of a directed graph in a shared memory architecture. The edges and vertices are added or deleted concurrently by fixed number of threads.
C Demetrescu +4 more
core +1 more source
Discrete Mathematics, 2009 AbstractBrualdi and Shanny [R.A. Brualdi, R.F. Shanny, Hamiltonian line graphs, J. Graph Theory 5 (1981) 307–314], Clark [L. Clark, On hamitonian line graphs, J. Graph Theory 8 (1984) 303–307] and Veldman [H.J. Veldman, On dominating and spanning circuits in graphs, Discrete Math.
Minmin Zong, Liming Xiong
openaire +2 more sources
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Efficient Generation of Geographically Accurate Transit Maps
, 2017 We present LOOM (Line-Ordering Optimized Maps), a fully automatic generator of geographically accurate transit maps. The input to LOOM is data about the lines of a given transit network, namely for each line, the sequence of stations it serves and the ...
Argyriou Evmorfia +3 more
core +1 more source