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Porcine reproductive and respiratory syndrome virus (PRRSV) is an important swine pathogen affecting the global swine industry. The first open reading frame 5 (ORF5)-based genetic lineage classification system describing global PRRSV-2 genetic diversity ...
Wannarat Yim-im+8 more
doaj +1 more source
Genetic markers for Clostridium difficile lineages linked to hypervirulence [PDF]
Rapid identification of hypervirulent Clostridium difficile strains is essential for preventing their spread. Recent completion of several full-length C. difficile genomes provided an excellent opportunity to identify potentially unique genes that characterize hypervirulent strains. Based on sequence comparisons between C. difficile strains we describe
Knetsch, C.W.+7 more
openaire +5 more sources
Conserved developmental processes and the formation of evolutionary novelties: examples from butterfly wings [PDF]
The origin and diversification of evolutionary novelties—lineage-specific traits of new adaptive value—is one of the key issues in evolutionary developmental biology. However, comparative analysis of the genetic and developmental bases of such traits can
De Celis J.F+5 more
core +2 more sources
Analysis of World-Scale Mitochondrial DNA Reveals the Origin and Migration Route of East Asia Goats
Despite much attention on the history of goat evolution, information on origin, demographic history, and expansion route remains controversial. To address these questions, we collected 4,189 published goat DNA sequences including 1,228 sequences from 57 ...
Weifeng Peng+19 more
doaj +1 more source
Dissemination of Enterococcal Genetic Lineages: A One Health Perspective
Enterococcus spp. are commensals of the gastrointestinal tracts of humans and animals and colonize a variety of niches such as water, soil, and food. Over the last three decades, enterococci have evolved as opportunistic pathogens, being considered ESKAPE pathogens responsible for hospital-associated infections.
Joana Monteiro Marques+4 more
openaire +3 more sources
Lineage dynamics of murine pancreatic development at single-cell resolution. [PDF]
Organogenesis requires the complex interactions of multiple cell lineages that coordinate their expansion, differentiation, and maturation over time.
Byrnes, Lauren E+8 more
core +2 more sources
Genetic and Cultural Reconstruction of the Migration of an Ancient Lineage
A rare R1a1 Y-haplogroup (Y-HG) L657 clade subtype designated as LPKSTR is found in most male members of a clan of “founder” families within the Goud Saraswat Brahmin community in Lotli town in Western India. TMRCA calculations using pairwise comparisons to control cohorts suggested a probable migration history distinct from the canonical narrative for
Anupuma Raina+3 more
openaire +3 more sources
Cell Behaviors and Genetic Lineages of the Mesencephalon and Rhombomere 1 [PDF]
Brain structures derived from the mesencephalon (mes) and rhombomere 1 (r1) modulate distinct motor and sensory modalities. The precise origin and cellular behaviors underpinning the cytoarchitectural organization of the mes and r1, however, are unknown.
Sandrine Millet+3 more
openaire +3 more sources
Are Synthetic Genomes Parts of a Genetic Lineage?
AbstractBiologists are nearing the creation of the first fully synthetic eukaryotic genome. Does this mean that we still soon be able to create genomes that are parts of an existing genetic lineage...
openaire +2 more sources
Genetic dissection of clonal lineage relationships with hydroxytamoxifen liposomes [PDF]
AbstractTargeted genetic dissection of tissues to identify precise cell populations has vast biological and therapeutic applications. Here we develop an approach, through the packaging and delivery of 4-hydroxytamoxifen liposomes (LiTMX), that enables localized induction of CreERT2 recombinase in mice.
Ryan C. Ransom+11 more
openaire +3 more sources