Results 91 to 100 of about 437,555 (335)

FINANCIAL STRUCTURE OPTIMIZATION BY USING A GOAL PROGRAMMING APPROACH

Croatian Operational Research Review, 2012
This paper proposes a new methodology for solving the multiple objective fractional linear programming problems using Taylor’s formula and goal programming techniques.
Tunjo Perić, Zoran Babić
doaj  

Cutting plane methods for general integer programming [PDF]

, 1993
Integer programming (IP) problems are difficult to solve due to the integer restrictions imposed on them. A technique for solving these problems is the cutting plane method.
Darby-Dowman, K, Hamid, FA, Mitra, G
core  

Multiparametric linear fractional functionals programming

Trabajos de Investigacion Operativa, 1989
Summary: A multiparametric linear fractional functionals program, with parameters appearing only in the objective function, is generated. The optimum solution of this parametric program is supposed to satisfy the constraints as equations only. It is also shown that the set of parameters forms a convex polyhedron.
openaire   +3 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Fuzzy goal programming approach for solving linear fractional programming problems with fuzzy conditions [PDF]

Journal of Fuzzy Extension and Applications
Predicting the exact outcome of a real-life problem, which may occur in various fields like the industrial or healthcare sector, is challenging. Due to high information uncertainty and complicated factors influencing the industrial sector, traditional ...
Rajeev Prasad, Indrani Maiti, Sapan Das, Surapati Pramanik, Tarni Mandal   +4 more
doaj   +1 more source

A space-time pseudospectral discretization method for solving diffusion optimal control problems with two-sided fractional derivatives

, 2018
We propose a direct numerical method for the solution of an optimal control problem governed by a two-side space-fractional diffusion equation. The presented method contains two main steps.
Ali, Mushtaq Salh, Bozorgnia, Farid, Khosravian-Arab, Hassan, Shamsi, Mostafa, Torres, Delfim F. M.   +4 more
core   +1 more source

On duality in linear fractional programming [PDF]

Proceedings of the Indian Academy of Sciences - Section A, 1980
In this paper, a dual of a given linear fractional program is defined and the weak, direct and converse duality theorems are proved. Both the primal and the dual are linear fractional programs. This duality theory leads to necessary and sufficient conditions for the optimality of a given feasible solution. A unmerical example is presented to illustrate
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Fractional programming for Stackelberg game under type-2 fuzzy environment [PDF]

Yugoslav Journal of Operations Research
This study intends to present a Stackelberg game model for design of the fractional type-2 fuzzy programming. In achieving this aspiration, we develop a probabilistic fuzzy multi-objective fractional linear programming where the entire parameters are of ...
Maiti Sumit Kumar, Roy Sankar Kumar, Saha Chinmay, Das Gora   +3 more
doaj   +1 more source