Results 121 to 130 of about 69,882 (311)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
صياغة وحل نماذج البرمجة الكسرية الخطية باستخدام طريقة لاكرانج المطورة
مجلة علوم ذي قار, 2019 In this paper Lagrange’s method was used to solve Fractional linear programming problems and then developed this method by using mathematical forms by which it can be possible to find the solution without using complex derivations.
رشيد بشير رحيمه
doaj
A new approach for solving fully fuzzy linear fractional programming problems using the multi-objective linear programming [PDF]
, 2016 Sapan Kumar Das +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Nearly Linear-Work Algorithms for Mixed Packing/Covering and Facility-Location Linear Programs
, 2014 We describe the first nearly linear-time approximation algorithms for explicitly given mixed packing/covering linear programs, and for (non-metric) fractional facility location.
Young, Neal E.
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
TOPSIS approach to linear fractional bi-level MODM problem based on fuzzy goal programming [PDF]
, 2014 Partha Pratim Dey +2 more
openalex +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Investigation of a fuzzy linear fractional programming (FLFP) solution [PDF]
Ritika Devi +3 more
openalex +1 more source