Results 71 to 80 of about 437,555 (335)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Globally Optimal Energy-Efficient Power Control and Receiver Design in Wireless Networks

, 2017
The characterization of the global maximum of energy efficiency (EE) problems in wireless networks is a challenging problem due to the non-convex nature of investigated problems in interference channels.
Björnson, Emil, Jorswieck, Eduard, Sanguinetti, Luca, Zappone, Alessio   +3 more
core   +4 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

استخدام خوارزمية طريقة تطوير مو لد قطع المستوي لإيجاد الحل العددي لمسائل البرمجة الكسرية [PDF]

Engineering and Technology Journal, 2008
There are many methods for solving Fractional Programming problems thatgetting the optimal solution of the problem where the values of variables arefractional numbers not integer numbers, But when there are conditions in theproblem that requires the ...
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

General parametric linear fractional programming

Metrika, 1972
This paper deals with the behaviour of solutions to a linear fractional programming problem when the coefficients of the objective function are allowed to vary.
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Logic Integer Programming Models for Signaling Networks

, 2008
We propose a static and a dynamic approach to model biological signaling networks, and show how each can be used to answer relevant biological questions. For this we use the two different mathematical tools of Propositional Logic and Integer Programming.
Haus U.-U., Kathrin Niermann, Klaus Truemper, Robert Weismantel, Saez-Rodriguez J., Utz-Uwe Haus   +5 more
core   +3 more sources

On Solving Linear Fractional Programming Problems

Modern Applied Science, 2013
يتم اقتراح طريقة جديدة وهي طريقة تقييد هدف المقام بناءً على طريقة البسيط لحل مشاكل البرمجة الكسرية الخطية. علاوة على ذلك، يتم اقتراح طريقة أخرى وهي طريقة التحلل والتقييد بناءً على مبدأ التحلل وطريقة تقييد هدف المقام للحصول على حل غامض أمثل لمشكلة البرمجة الكسرية الخطية الغامضة بالكامل. يتم توضيح إجراءات الطرق المقترحة بالأمثلة العددية.
P. Pandian, Jayalakshmi Mohan
openaire   +2 more sources